Spatial-temporal organization of subcortical brain functions during immune responses.

In the course of long-term experiments on rabbits, functional dynamics of subcortical structures were studied by recording background (DC) and evoked potentials (EP) during immune responses elicited to various antigens. During the first day of the immune response process to the different antigens, changes in hypothalamus functioning were similar and occurred with a latency of 9 to 31 min. Inductive and productive primary immune responses were accompanied by successive phasic changes in the functioning of a number of subcortical structures.