抗胆碱酯酶药物会影响猫皮层视觉诱发电位的对比度增益。

Anticholinesterase agents affect contrast gain of the cat cortical visual evoked potential.

作者信息

DeBruyn E J, Gajewski Y A, Bonds A B

出版信息

Neurosci Lett. 1986 Nov 21;71(3):311-6. doi: 10.1016/0304-3940(86)90639-7.

Abstract

The effects of the anticholinesterase agents physostigmine, pyridostigmine, diisopropylfluorophosphate and soman on the cortical visual evoked potential (VEP) were examined using phase reversed sine wave gratings of varying contrasts. All 4 agents decreased the slope (gain) of the response vs log contrast function while the intercept with the noise level (threshold, an indicator of contrast sensitivity) was unaffected. These results suggest that anticholinesterases modify the VEP by changing a contrast gain control mechanism.

摘要

使用不同对比度的相位反转正弦波光栅，研究了抗胆碱酯酶药物毒扁豆碱、吡啶斯的明、二异丙基氟磷酸酯和梭曼对皮层视觉诱发电位（VEP）的影响。所有这4种药物均降低了反应与对数对比度函数的斜率（增益），而与噪声水平的截距（阈值，对比度敏感度的指标）未受影响。这些结果表明，抗胆碱酯酶药物通过改变对比度增益控制机制来改变视觉诱发电位。