The effects of diisopropylfluorophosphate on spatial frequency responsivity in the cat visual system.

Visual-evoked responses to counterphased gratings were recorded from area 17 of cat visual cortex before and after diisopropylfluorophosphate (DFP) administration. DFP produced effects similar to those obtained following physostigmine sulfate administration, in that responses to low spatial frequencies were preferentially reduced. The time course of the effects was quite different for the two types of drugs, and for high doses of DFP responses to all spatial frequencies were approximately uniformly depressed or abolished.