硅烷对2-芳基-2-吲唑的光促进自由基硅基化反应
Photopromoted Free Radical Silylation of 2-Aryl-2-indazoles with Silanes.
作者信息
Tian Yunfei, Zheng Luping, Guo Dongyu, Miao Yuyan, Li Lijun, Fu Weijun, Li Zejiang
机构信息
College of Chemistry and Chemical Engineering, Key Laboratory of Fuction-Oriented Porous Materials of Henan Province, Luoyang Normal University, Luoyang, Henan 471934, P. R. China.
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, College of Chemistry & Materials Science, and Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding, Hebei 071002, P. R. China.
出版信息
J Org Chem. 2023 Dec 1;88(23):16671-16678. doi: 10.1021/acs.joc.3c02232. Epub 2023 Nov 16.
Photoinduced silylation of silanes with 2-aryl-2-indazoles was developed under mild conditions, which could efficiently result in diverse 3-silylated 2-indazoles with good substrate scopes. A series of scaled-up to gram level and radical capture operations were performed in this system. Meanwhile, a bioactive molecule was tolerated well under typical conditions.
在温和条件下开发了硅烷与2-芳基-2-吲唑的光诱导硅烷化反应，该反应能高效地生成具有良好底物范围的多种3-硅烷化2-吲唑。在该体系中进行了一系列放大至克级的反应以及自由基捕获操作。同时，一种生物活性分子在典型条件下耐受性良好。
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