Calderillo-Ruíz Germán, Díaz-Romero María Consuelo, Carbajal-López Berenice, Herrera-Martínez Marytere, Ruiz-García Erika, Leon-Takahashi Alberto M, López-Basave Horacio Noé, Meneses-García Abelardo, Herrera-Gomez Ángel
Gastrointestinal Functional Unit, National Cancer Institute, Mexico City, Mexico.
Clinical Research Department-Gastrointestinal Functional, National Cancer Institute, Mexico City, Mexico.
J Gastrointest Oncol. 2023 Oct 31;14(5):2018-2027. doi: 10.21037/jgo-23-259. Epub 2023 Oct 27.
Incidence of young patients (aged 40 years or younger) diagnosed with gastric carcinoma has increased worldwide. Young GC diagnosis, have clinicopathological features that differ from elderly, and is correlated with bad prognosis factors. The purpose of this work is to describe the prevalence, clinic-pathological features, and prognosis of overall survival (OS) of young Latin-American patients with GC.
Retrospective, observational study. Included patients treated at the National Cancer Institute [2004-2020]. Statistical analysis: χ and -test, Kaplan-Meier, Log-Rank and Cox-Regression. Statistical significance differences were assessed when P was bilaterally <0.05.
A total of 2,543 patients fulfilled the inclusion criteria. Young-patients were predominantly female (54%), with diffuse-type adenocarcinoma (68%), signet-ring-cell (72%), poor-differentiation (90%), and metastatic (79%). In OS analysis, patients with metastatic disease, showed differences regarding age, young patients reported a median-OS of 8 versus 13 months for elderly patients (P=0.001). Among young patients, differences were also observed regarding gender, young-female patients had a median-OS of 5 versus 11 months for young-man (P=0.001).
This is one of the pioneer studies correlating age with gender and the prognostic features of bad prognosis in Latin-American population. Besides, supports the idea that a global effort is required to improve awareness, prevention, and early diagnosis of GC.
在全球范围内，被诊断为胃癌的年轻患者（40岁及以下）的发病率有所上升。年轻胃癌患者具有与老年患者不同的临床病理特征，且与不良预后因素相关。本研究的目的是描述拉丁美洲年轻胃癌患者的患病率、临床病理特征以及总生存期（OS）的预后情况。
回顾性观察研究。纳入2004年至2020年在国家癌症研究所接受治疗的患者。统计分析：χ²检验和t检验、Kaplan-Meier法、Log-Rank检验和Cox回归分析。当双侧P<0.05时评估统计学显著性差异。
共有2543例患者符合纳入标准。年轻患者以女性为主（54%），主要为弥漫型腺癌（68%）、印戒细胞癌（72%）、低分化癌（90%）以及转移性癌（79%）。在总生存期分析中，有转移疾病的患者在年龄方面存在差异，年轻患者的中位总生存期为8个月，而老年患者为13个月（P=0.001）。在年轻患者中，性别方面也存在差异，年轻女性患者的中位总生存期为5个月，而年轻男性为11个月（P=0.001）。
这是将年龄与性别以及拉丁美洲人群不良预后的预后特征相关联的开创性研究之一。此外，支持了需要全球共同努力以提高对胃癌的认识、预防和早期诊断的观点。
