DeRenzi Anthony D, Bowen Audrey
HCA Florida North Florida Hospital, Gainesville, FL.
UCF/HCA Healthcare GME Consortium of North Florida.
HCA Healthc J Med. 2023 Oct 30;4(5):377-382. doi: 10.36518/2689-0216.1095. eCollection 2023.
Hepatoblastoma is a rare pediatric cancer. Approximately 100 cases of hepatoblastoma are reported per year. Due to the limited incidence of this disorder an internationally agreed-upon criteria was developed to classify patients as standard or high-risk. Studies involving chemotherapeutic agents, surgery, and liver transplants have been demonstrated to improve the disease-free survival rate. The combination of chemotherapeutic agents and surgery demonstrated the ability of these regimens to downgrade the initial diagnostic staging of tumors and transform previously unresectable tumors into resectable tumors.
The following case of hepatoblastoma presents a 4-year-old male who presented to the emergency department with an upper respiratory infection symptom and was found to have hepatomegaly. The patient was later classified as high-risk, unresectable hepatoblastoma.
Hepatoblastoma is a rare liver cancer in children with an annual incidence of 1.5 cases per million. With PRETEXT staging criterion, therapeutic options such as cisplatin/doxorubicin combination, radiotherapy, and lobectomy, have become the standard of care for this condition. Many trials have demonstrated these therapeutic options to successfully improve the survivability rate of patients affected by hepatoblastoma, downgrading tumors from advanced PRETEXT stages and enabling previously unresectable tumors to be considered resectable.
肝母细胞瘤是一种罕见的儿童癌症。每年报告的肝母细胞瘤病例约有100例。由于这种疾病的发病率有限，因此制定了国际公认的标准，将患者分为标准风险或高风险。涉及化疗药物、手术和肝移植的研究已证明可提高无病生存率。化疗药物与手术的联合使用证明了这些治疗方案能够降低肿瘤的初始诊断分期，并将以前无法切除的肿瘤转变为可切除的肿瘤。
以下肝母细胞瘤病例为一名4岁男性，因上呼吸道感染症状就诊于急诊科，检查发现肝肿大。该患者后来被归类为高风险、不可切除的肝母细胞瘤。
肝母细胞瘤是一种罕见的儿童肝癌，年发病率为每百万人口1.5例。根据PRETEXT分期标准，顺铂/阿霉素联合化疗、放疗和肝叶切除术等治疗选择已成为这种疾病的标准治疗方法。许多试验表明，这些治疗选择能够成功提高肝母细胞瘤患者的生存率，将肿瘤从晚期PRETEXT分期降级，并使以前无法切除的肿瘤被视为可切除。
