Hwang Eun Jung, Korde Sayli, Han Ying, Sambangi Jaydeep, Lian Bowen, Owusu-Ofori Ama, Diasamidze Megi, Wong Lea M, Pickering Nadine, Begin Sam
Cell Biology and Anatomy, Chicago Medical School, Stanson Toshok Center for Brain Function and Repair, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
Department of Neuroscience, Lake Forest College, Lake Forest, IL 60045, USA.
bioRxiv. 2023 Oct 23:2023.10.21.563408. doi: 10.1101/2023.10.21.563408.
Aging can compromise decision-making and learning, potentially due to reduced exploratory behaviors crucial for novel problem-solving. We posit that invigorating exploration could mitigate these declines. Supporting this hypothesis, we found that older mice mirrored human aging, displaying less exploration and learning during decision-making, but optogenetic stimulation of their posterior parietal cortex boosted initial exploration, subsequently improving learning. Thus, enhancing exploration-driven learning could be a key to countering cognitive aging.
衰老可能会损害决策和学习能力，这可能是由于对解决新问题至关重要的探索行为减少所致。我们认为，激发探索可以减轻这些衰退。支持这一假设的是，我们发现老年小鼠反映了人类衰老的情况，在决策过程中表现出较少的探索和学习能力，但对其顶叶后部进行光遗传学刺激可增强初始探索，随后改善学习能力。因此，增强由探索驱动的学习可能是对抗认知衰老的关键。
