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响尾蛇咬伤致早发性呼吸肌瘫痪:病例研究。

Early-Onset Respiratory Muscle Paralysis in Crotalic Envenomation: A Case Study.

机构信息

Hospital João XXIII, Centro de Informação e Assistência Toxicológica de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil.

Universidade Federal de São Paulo, São Paulo, Brasil.

出版信息

Rev Soc Bras Med Trop. 2023 Nov 10;56:e03742023. doi: 10.1590/0037-8682-0374-2023. eCollection 2023.

DOI:10.1590/0037-8682-0374-2023
PMID:37970880
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10637731/
Abstract

Crotalic envenomation is responsible for approximately 8%-13% of ophidism cases in Brazil, yet it is associated with the highest mortality among snakes. We describe the case of a patient bitten by a rattlesnake who developed ventilatory muscle paralysis within hours after envenomation. While diaphragmatic paralysis is a rare late neurotoxic event following crotalic envenomation, in this case, paralysis occurred early but was rapidly reversed after antivenom administration. This report discusses potential contributing factors based on a comprehensive literature review.

摘要

响尾蛇咬伤约占巴西蛇伤病例的 8%-13%,但其死亡率却是所有蛇类中最高的。我们报告了 1 例响尾蛇咬伤患者,在咬伤后数小时内出现呼吸肌瘫痪。膈肌瘫痪是响尾蛇咬伤后罕见的迟发性神经毒性事件,但本例患者的瘫痪发生较早,在使用抗蛇毒血清治疗后迅速逆转。本报告基于全面的文献复习讨论了潜在的促成因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d18/10637731/9ab9bae9e409/1678-9849-rsbmt-56-e0374-2023-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d18/10637731/80d09874c0b6/1678-9849-rsbmt-56-e0374-2023-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d18/10637731/9ab9bae9e409/1678-9849-rsbmt-56-e0374-2023-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d18/10637731/80d09874c0b6/1678-9849-rsbmt-56-e0374-2023-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d18/10637731/9ab9bae9e409/1678-9849-rsbmt-56-e0374-2023-gf2.jpg

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本文引用的文献

1
Clinical, Laboratory, and Therapeutic Aspects of (South American Rattlesnake) Victims: A Literature Review.(中南美的响尾蛇)受害者的临床、实验室和治疗方面:文献综述。
Biomed Res Int. 2019 Aug 5;2019:1345923. doi: 10.1155/2019/1345923. eCollection 2019.
2
Crotalus durissus terrificus (viperidae; crotalinae) envenomation: Respiratory failure and treatment with antivipmyn TRI antivenom.杜氏响尾蛇(蝰蛇科;响尾蛇亚科)咬伤:呼吸衰竭及使用抗蝰蛇毒血清TRI进行治疗
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巴西亚马逊地区的响尾蛇咬伤:临床流行病学、空间分布及生态决定因素
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Crotalid snake envenomation.响尾蛇科蛇咬伤中毒
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Time factor in the detection of circulating whole venom and crotoxin and efficacy of antivenom therapy in patients envenomed by Crotalus durissus.检测循环全毒液和响尾蛇毒素的时间因素以及抗蛇毒血清疗法对杜氏响尾蛇咬伤患者的疗效
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Structure and function relationship of crotoxin, a heterodimeric neurotoxic phospholipase A2 from the venom of a South-American rattlesnake.南美响尾蛇毒液中的异二聚体神经毒性磷脂酶A2——响尾蛇毒素的结构与功能关系
Adv Exp Med Biol. 1996;391:197-202. doi: 10.1007/978-1-4613-0361-9_12.
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Neurotoxins from the South American rattle snake venom.来自南美响尾蛇毒液的神经毒素。
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10
[Respiratory involvement secondary to crotalid ophidian bite (Crotalus durissus)].[响尾蛇咬伤(杜氏响尾蛇)继发的呼吸系统受累]
Rev Inst Med Trop Sao Paulo. 1991 Jul-Aug;33(4):251-5.