Medical Department, Internal Medicine and Geriatrics Unit, IRCCS INRCA, Ancona, Italy.
Department of Clinical and Molecular Sciences, University "Politecnica delle Marche," Ancona, Italy.
J Palliat Med. 2024 Mar;27(3):367-375. doi: 10.1089/jpm.2023.0038. Epub 2023 Nov 15.
It is essential to establish both the appropriateness of palliative care (PC) and the prognosis in daily clinical practice to guide decision making in the management of older people with multiple advanced chronic diseases. We assessed patients who were appropriate for PC using the NECPAL tool in a hospitalized older population and then we investigated its predictive validity on one-year mortality compared with the multidimensional prognostic index (MPI), a validated geriatric prognostic tool. Prospective cohort study. We enrolled 103 older adults hospitalized for acute medical and surgical conditions in a geriatric hospital in Italy. The variables of interest were obtained at baseline through interviews of the ward medical staff and by consulting the computerized medical records. Long-term mortality (one-year) was assessed through the analysis of data acquired from hospital or territorial databases or through telephone contact with caregivers. Mean age was 86.8 ± 7.2 years, with a female prevalence of 54.4%. Prevalence of NECPAL+ patients was 65.1%. MPI low risk: 30.1%; moderate risk: 41.7%; severe risk: 28.2%. Patients deceased during follow-up were 54.4%. NECPAL+ patients were more likely to die, even after adjusting for age, sex, and MPI score (hazard ratio [HR] 2.7, = 0.020). All the NECPAL categories were associated with one-year mortality. MPI showed a better predictive power than NECPAL (area under the curve [AUC] 0.85 vs. 0.75, = 0.030). After the exclusion of "Comorbidity: ≥2 concurrent diseases" item from NECPAL, its AUC increased to 0.78 with no statistically significant differences from MPI ( = 0.122). NECPAL is useful to identify the appropriateness of PC in hospitalized older adults, also allowing to predict long-term mortality with a performance similar to that of a validated geriatric prognostic tool.
在日常临床实践中,确定姑息治疗(PC)的适宜性和预后对于指导老年人多种晚期慢性疾病的管理决策至关重要。我们使用 NECPAL 工具评估了住院老年人群中适合 PC 的患者,然后研究了其与多维预后指数(MPI)相比在预测一年死亡率方面的预测效度,MPI 是一种经过验证的老年预后工具。前瞻性队列研究。我们在意大利的一家老年医院招募了 103 名因急性内科和外科疾病住院的老年人。通过病房医护人员的访谈和查阅电子病历获得了感兴趣的变量。通过分析从医院或地区数据库获得的数据或通过与护理人员电话联系评估了长期死亡率(一年)。平均年龄为 86.8 ± 7.2 岁,女性患病率为 54.4%。NECPAL+患者的患病率为 65.1%。MPI 低危:30.1%;中危:41.7%;高危:28.2%。随访期间死亡的患者为 54.4%。即使在校正了年龄、性别和 MPI 评分后,NECPAL+患者死亡的可能性仍然更高(风险比 [HR] 2.7, = 0.020)。所有 NECPAL 类别均与一年死亡率相关。MPI 比 NECPAL 具有更好的预测能力(曲线下面积 [AUC] 0.85 与 0.75, = 0.030)。从 NECPAL 中排除“合并症:≥2 种并存疾病”项目后,其 AUC 增加到 0.78,与 MPI 无统计学差异( = 0.122)。NECPAL 可用于识别住院老年患者 PC 的适宜性,并且可以预测长期死亡率,其性能与经过验证的老年预后工具相似。