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使用NECPAL工具对危重症患者姑息治疗需求的早期检测

Early Detection of Palliative Care Needs in Critically Ill Patients Using the NECPAL Tool.

作者信息

Spadaro Savino, Azzolina Danila, Vuan Adelaide, Colasanto Luigi, Manzetto Cristiana, Busnardo Alessandra, Filieri Grazia, Fagogeni Persefoni, Ganzaroli Francesco, Gamanji Viorel, Poles Giovanni, Spinazzola Giorgia, Volta Carlo Alberto, Scaramuzzo Gaetano, Gulmini Loretta

机构信息

Emergency Department, Azienda Ospedaliera Universitaria di Ferrara, Aldo Moro, 8, 441232 Ferrara, Italy.

Department of Translational Medicine, University of Ferrara, 44124 Ferrara, Italy.

出版信息

J Clin Med. 2025 Sep 4;14(17):6244. doi: 10.3390/jcm14176244.

Abstract

: Palliative care is essential in intensive care, improving symptom control, quality of life, and reducing hospital stays without increasing mortality. However, early identification of patients who could benefit remains a major challenge. This study aimed to evaluate the NECesidades PALiativas (NECPAL) tool's effectiveness in identifying ICU patients in Italy with PC needs. : This prospective observational study was conducted from March 2024 to February 2025. Adult ICU patients (≥18 years), admitted for at least 24 h and meeting NECPAL eligibility criteria (e.g., cancer, COPD, heart failure, dementia, and frailty), were evaluated using the NECPAL tool. : A total of 85 patients were enrolled; 28 (32.9%) were classified as NECPAL-positive and 57 (67.1%) as NECPAL-negative. NECPAL-positive patients had a significantly higher ICU mortality rate (32.1%) compared to NECPAL-negative patients (1.8%) ( < 0.001). The median ICU length of stay was slightly longer for NECPAL-positive patients [11.0 days (IQR: 8.0-16.2)] versus NECPAL-negative patients [10.0 days (IQR: 5.0-14.0)], though not statistically significant. Multivariable Firth penalized logistic regression confirmed NECPAL positivity as an independent predictor of ICU mortality (OR 19.55; 95% CI: 3.06-124.93; < 0.001). : In this study, NECPAL identified about one-third of ICU patients as having palliative care needs, who also showed a higher mortality risk. Integration with ICU severity scores may improve early recognition of these needs, warranting validation in larger multicenter studies.

摘要

姑息治疗在重症监护中至关重要,它能改善症状控制、提高生活质量并缩短住院时间,且不增加死亡率。然而,早期识别可能受益的患者仍然是一项重大挑战。本研究旨在评估NECesidades PALiativas(NECPAL)工具在识别意大利有姑息治疗需求的重症监护病房(ICU)患者方面的有效性。 :这项前瞻性观察性研究于2024年3月至2025年2月进行。成年ICU患者(≥18岁),入院至少24小时且符合NECPAL纳入标准(如癌症、慢性阻塞性肺疾病、心力衰竭、痴呆和虚弱),使用NECPAL工具进行评估。 :共纳入85例患者;28例(32.9%)被分类为NECPAL阳性,57例(67.1%)为NECPAL阴性。与NECPAL阴性患者(1.8%)相比,NECPAL阳性患者的ICU死亡率显著更高(32.1%)(<0.001)。NECPAL阳性患者的ICU中位住院时间[11.0天(四分位间距:8.0 - 16.2)]比NECPAL阴性患者[10.0天(四分位间距:5.0 - 14.0)]略长,尽管无统计学意义。多变量费思惩罚逻辑回归证实NECPAL阳性是ICU死亡率的独立预测因素(比值比19.55;95%置信区间:3.06 - 124.93;<0.001)。 :在本研究中,NECPAL识别出约三分之一的ICU患者有姑息治疗需求,这些患者也显示出较高的死亡风险。与ICU严重程度评分相结合可能会改善对这些需求的早期识别,值得在更大规模的多中心研究中进行验证。

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