Institute of Biomedicine and FICAN West Cancer Centre, University of Turku, 20520, Turku, Finland.
Johns Hopkins University School of Medicine, 21205, Baltimore, MD, USA.
Curr Opin Cell Biol. 2023 Dec;85:102280. doi: 10.1016/j.ceb.2023.102280. Epub 2023 Nov 15.
The intermediate filament (IF) cytoskeleton supports cellular structural integrity, particularly in response to mechanical stress. The most abundant IF proteins in mature cardiomyocytes are desmin and lamins. The desmin network tethers the contractile apparatus and organelles to the nuclear envelope and the sarcolemma, while lamins, as components of the nuclear lamina, provide structural stability to the nucleus and the genome. Mutations in desmin or A-type lamins typically result in cardiomyopathies and recent studies emphasized the synergistic roles of desmin and lamins in the maintenance of nuclear integrity in cardiac myocytes. Here we explore the emerging roles of the interdependent relationship between desmin and lamins in providing resilience to nuclear structure while transducing extracellular mechanical cues into the nucleus.
中间丝（IF）细胞骨架支持细胞结构的完整性，尤其是在应对机械应激时。成熟心肌细胞中最丰富的 IF 蛋白是结蛋白和核纤层蛋白。结蛋白网络将收缩装置和细胞器固定到核膜和肌膜上，而核纤层蛋白作为核纤层的组成部分，为核和基因组提供结构稳定性。结蛋白或 A 型核纤层蛋白的突变通常导致心肌病，最近的研究强调了结蛋白和核纤层蛋白在维持心肌细胞核完整性方面的协同作用。在这里，我们探讨了结蛋白和核纤层蛋白之间相互依存关系在传递细胞外机械信号到核内的同时，为核结构提供弹性的新兴作用。
