Biology, Chromosome Biology Lab (CBL), Indian Institute of Science Education and Research (IISER), Dr. Homi Bhabha Road, Pune, 411008, India.
Biol Cell. 2021 Jul;113(7):295-310. doi: 10.1111/boc.202000160. Epub 2021 Mar 12.
Nuclear lamins are type V intermediate filament proteins that form a filamentous meshwork beneath the inner nuclear membrane. Additionally, a sub-population of A- and B-type lamins localizes in the nuclear interior. The nuclear lamina protects the nucleus from mechanical stress and mediates nucleo-cytoskeletal coupling. Lamins form a scaffold that partially tethers chromatin at the nuclear envelope. The nuclear lamina also stabilises protein-protein interactions involved in gene regulation and DNA repair. The lamin-based protein sub-complexes are implicated in both nuclear and cytoskeletal organisation, the mechanical stability of the nucleus, genome organisation, transcriptional regulation, genome stability and cellular differentiation. Here, we review recent research on nuclear lamins and unique roles of A- and B-type lamins in modulating various nuclear processes and their impact on cell function.
核纤层蛋白是第五类中间丝蛋白，形成于内核膜下的纤维网格状结构。此外，A 型和 B 型核纤层蛋白的亚群定位于核内。核纤层保护细胞核免受机械应力，并介导核质骨架偶联。核纤层形成一个支架，部分将染色质固定在核膜上。核纤层还稳定参与基因调控和 DNA 修复的蛋白质-蛋白质相互作用。基于核纤层的蛋白亚复合物参与核和细胞骨架的组织、细胞核的机械稳定性、基因组组织、转录调控、基因组稳定性和细胞分化。在这里，我们回顾了核纤层蛋白的最新研究以及 A 型和 B 型核纤层蛋白在调节各种核过程中的独特作用及其对细胞功能的影响。
