Stahl Marisa, Koletzko Sibylle, Andrén Aronsson Carin, Lindfors Katri, Liu Edwin, Agardh Daniel
Pediatric Gastroenterology, Hepatology, and Nutrition, Digestive Health Institute, Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Department of Pediatrics, Dr von Hauner Kinderspital, LMU University Hospital, LMU Munich, Munich, Germany; Department of Pediatrics, Gastroenterology and Nutrition, School of Medicine Collegium Medicum University of Warmia and Mazury, Olsztyn, Poland.
Lancet Child Adolesc Health. 2024 Jan;8(1):63-74. doi: 10.1016/S2352-4642(23)00232-8. Epub 2023 Nov 14.
Paediatric prospective studies of coeliac disease with longitudinal collection of biological samples and clinical data offer a unique perspective on disease risk. This Review highlights the information now available from international paediatric prospective studies on genetic and environmental risk factors for coeliac disease. In addition, recent omics studies have made it possible to study complex interactions between genetic and environmental factors and thereby further our insight into the causes of the disease. In the future, paediatric prospective studies will be able to provide more detailed risk prediction models combining genes, the environment, and biological corroboration from multiomics. Such studies could also contribute to biomarker development and an improved understanding of disease pathogenesis.
对乳糜泻进行儿科前瞻性研究，并纵向收集生物样本和临床数据，为疾病风险提供了独特的视角。本综述重点介绍了目前国际儿科前瞻性研究中关于乳糜泻遗传和环境风险因素的现有信息。此外，最近的组学研究使研究遗传和环境因素之间的复杂相互作用成为可能，从而进一步加深我们对该疾病病因的理解。未来，儿科前瞻性研究将能够提供更详细的风险预测模型，将基因、环境和来自多组学的生物学证据结合起来。此类研究还可能有助于生物标志物的开发，并增进对疾病发病机制的理解。
