Dennis N R, Stokes C R
J Med Genet. 1978 Feb;15(1):20-2. doi: 10.1136/jmg.15.1.20.
Among 73 offspring of parents with coeliac disease, 4 were affected, including 1 in whom the diagnosis was made as a result of the study. The coeliac parents of all 4 were HLA-B8 positive, but 1 affected child had failed to inherit his affected parent's B antigen. The findings are consistent with the hypothesis that an allele affecting liability to coeliac disease is in linkage disequilibrium with HLA-B8.
在患有乳糜泻的父母的73名后代中，有4人患病，其中1人是由于该研究才得以确诊。所有4名患病后代的乳糜泻父母均为HLA - B8阳性，但有1名患病儿童未能遗传其患病父母的B抗原。这些发现与以下假设一致：影响乳糜泻易感性的一个等位基因与HLA - B8处于连锁不平衡状态。
