患者子女患乳糜泻的风险及HLA基因型的影响。
Risk of coeliac disease in children of patients and effect of HLA genotype.
作者信息
Dennis N R, Stokes C R
出版信息
J Med Genet. 1978 Feb;15(1):20-2. doi: 10.1136/jmg.15.1.20.
Abstract
Among 73 offspring of parents with coeliac disease, 4 were affected, including 1 in whom the diagnosis was made as a result of the study. The coeliac parents of all 4 were HLA-B8 positive, but 1 affected child had failed to inherit his affected parent's B antigen. The findings are consistent with the hypothesis that an allele affecting liability to coeliac disease is in linkage disequilibrium with HLA-B8.
摘要
在患有乳糜泻的父母的73名后代中，有4人患病，其中1人是由于该研究才得以确诊。所有4名患病后代的乳糜泻父母均为HLA - B8阳性，但有1名患病儿童未能遗传其患病父母的B抗原。这些发现与以下假设一致：影响乳糜泻易感性的一个等位基因与HLA - B8处于连锁不平衡状态。
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本文引用的文献
1
STUDIES OF THE FAMILIAL NATURE OF CELIAC SPRUE USING BIOPSY OF THE SMALL INTESTINE.
N Engl J Med. 1965 Mar 4;272:448-56. doi: 10.1056/NEJM196503042720903.
2
The inheritance of coeliac disease.
Ann Hum Genet. 1959 Jul;23:266-78. doi: 10.1111/j.1469-1809.1959.tb01470.x.
3
Predominance of histocompatibility antigen HL-A8 in patients with gluten-sensitive enteropathy.
J Clin Invest. 1972 Jun;51(6):1602-5. doi: 10.1172/JCI106958.
4
A family study of coeliac disease.
J Med Genet. 1975 Mar;12(1):79-82. doi: 10.1136/jmg.12.1.79.
5
Familial aspects of coeliac disease.
Q J Med. 1976 Oct;45(180):567-82.
6
HLA-DW3 associated with coeliac disease.
Lancet. 1976 Mar 6;1(7958):506-8. doi: 10.1016/s0140-6736(76)90294-4.
7
Letter: Small-intestinal histology in coeliac disease.
Lancet. 1975 Sep 20;2(7934):550. doi: 10.1016/s0140-6736(75)90920-4.
8
Letter: Small-intestinal histology in coeliac disease.
Lancet. 1975 Aug 30;2(7931):418. doi: 10.1016/s0140-6736(75)92943-8.
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