Rouvas Alexandros, Theodossiadis Panagiotis, Georgalas Ilias, Gouliopoulos Nikolaos
2nd Department of Ophthalmology, Medical School of National and Kapodistrian University of Athens, 'Attikon' General Hospital Athens, Haidari, Athens, Greece; and.
1st Department of Ophthalmology, Medical School of National and Kapodistrian University of Athens, G. Gennimatas Hospital, Holargos, Athens, Greece.
Retin Cases Brief Rep. 2025 Jan 1;19(1):125-128. doi: 10.1097/ICB.0000000000001515.
To present a case of a patient with bilateral wet age-related macular degeneration who was unilaterally treated with intravitreal aflibercept injections (IAIs) and the disease status in the fellow eye ameliorated after an IAI.
Retrospective case report.
A 72-year-old woman was diagnosed with wet and dry age-related macular degeneration in her right eye and left eye, respectively. In the right eye, treatment strategy comprised three monthly IAIs, followed by reinjections according to need, whereas optical coherence tomography scans were performed before IAIs. One month after the second IAI, subretinal fluid developed in the left eye. One week later, an IAI was applied in the right eye; 2 days later, the disease status in the left eye was assessed by fluorescein angiography and optical coherence tomography. Surprisingly, in the left eye, subretinal fluid completely resolved and fluorescein angiography did not detect leakage, highlighting the absence of an active choroidal neovascularization. The short interval between IAI and the resolution of exudative phenomena in the other eye is suggestive of a beneficial effect in the contralateral eye.
In this article, we showed that an IAI had an effect to the fellow untreated eye. Our observation is consistent with active aflibercept in the systemic circulation. To the best of our knowledge, no other report in the literature has demonstrated this effect of aflibercept in wet age-related macular degeneration.
报告一例双侧湿性年龄相关性黄斑变性患者，其一只眼接受玻璃体内注射阿柏西普（IAIs）治疗，对侧眼在接受一次IAIs后病情改善。
回顾性病例报告。
一名72岁女性，右眼和左眼分别被诊断为湿性和干性年龄相关性黄斑变性。右眼的治疗策略包括每月进行3次IAIs，随后根据需要再次注射，在进行IAIs之前进行光学相干断层扫描。第二次IAIs后1个月，左眼出现视网膜下液。1周后，右眼进行了一次IAIs；2天后，通过荧光素血管造影和光学相干断层扫描评估左眼的病情。令人惊讶的是，左眼的视网膜下液完全消退，荧光素血管造影未检测到渗漏，表明不存在活跃的脉络膜新生血管。IAIs与对侧眼渗出性现象消退之间的短时间间隔提示对侧眼有有益作用。
在本文中，我们表明IAIs对未治疗的对侧眼有作用。我们的观察结果与全身循环中存在活性阿柏西普一致。据我们所知，文献中没有其他报告证明阿柏西普在湿性年龄相关性黄斑变性中有这种作用。
