一名儿科患者接种新冠疫苗后发生抗N-甲基-D-天冬氨酸受体自身免疫性脑炎：病例报告
Anti-NMDA Autoimmune Encephalitis Post-COVID-19 Vaccination in a Pediatric Patient: A Case Report.
作者信息
Alabssi Haila, Almulhim Nouf F, Al-Omari Mohammed, Safar Ayat H
机构信息
College of Medicine, Imam Abdulrahman Bin Faisal University, Eastern Province, Saudi Arabia.
Department of Pediatrics, King Fahd Hospital of the University, AlKhobar, Eastern Province, Saudi Arabia.
出版信息
Neuropediatrics. 2024 Apr;55(2):124-128. doi: 10.1055/a-2212-6936. Epub 2023 Nov 16.
Post-coronavirus disease 2019 (COVID-19) vaccination encephalitis is rarely reported particularly in the pediatric population. Herein, we report the first case of postvaccination anti-N-methyl-d-aspartate (NMDA) encephalitis in close temporal association with receiving COVID-19 vaccine in a pediatric patient. The patient is a 13-year-old female who received the first dose of the Pfizer-BioNTech COVID-19 vaccine and presented with subacute neurological and psychiatric symptoms and eventually confirmed the diagnosis of anti-NMDA autoimmune encephalitis. The patient recovered after receiving intravenous immunoglobulins and steroids.
2019冠状病毒病（COVID-19）疫苗接种后脑炎鲜有报道，尤其是在儿科人群中。在此，我们报告首例在儿科患者中与接种COVID-19疫苗在时间上密切相关的接种后抗N-甲基-D-天冬氨酸（NMDA）受体脑炎病例。该患者为一名13岁女性，接种了第一剂辉瑞- BioNTech COVID-19疫苗，出现亚急性神经和精神症状，最终确诊为抗NMDA自身免疫性脑炎。患者在接受静脉注射免疫球蛋白和类固醇治疗后康复。
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