Department of Nephrology, Ghent University Hospital, Ghent, Belgium.
Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.
Adv Clin Chem. 2023;117:53-102. doi: 10.1016/bs.acc.2023.08.005. Epub 2023 Sep 19.
Advanced glycation end products (AGEs), by-products of glucose metabolism, have been linked to the emergence of cardiovascular disorders (CVD). AGEs can cause tissue damage in four different ways: (1) by altering protein function, (2) by crosslinking proteins, which makes tissue stiffer, (3) by causing the generation of free radicals, and (4) by activating an inflammatory response after binding particular AGE receptors, such as the receptor for advanced glycation end products (RAGE). It is suggested that the soluble form of RAGE (sRAGE) blocks ligand-mediated pro-inflammatory and oxidant activities by serving as a decoy. Therefore, several studies have investigated the possible anti-inflammatory and anti-oxidant characteristics of sRAGE, which may help lower the risk of CVD. According to the results of various studies, the relationship between circulating sRAGE, cRAGE, and esRAGE and CVD is inconsistent. To establish the potential function of sRAGE as a therapeutic target in the treatment of cardiovascular illnesses, additional studies are required to better understand the relationship between sRAGE and CVD. In this review, we explored the potential function of sRAGE in different CVD, highlighting unanswered concerns and outlining the possibilities for further investigation.
糖基化终产物 (AGEs) 是葡萄糖代谢的副产物，与心血管疾病 (CVD) 的出现有关。AGEs 可以通过以下四种不同的方式造成组织损伤：(1) 改变蛋白质功能，(2) 交联蛋白质，使组织变硬，(3) 产生自由基，(4) 通过与特定的 AGE 受体（如晚期糖基化终产物受体 (RAGE)）结合后引发炎症反应。可溶性 RAGE（sRAGE）被认为通过充当诱饵来阻断配体介导的促炎和氧化剂活性。因此，许多研究已经研究了 sRAGE 的可能的抗炎和抗氧化特性，这可能有助于降低 CVD 的风险。根据不同研究的结果，循环 sRAGE、cRAGE 和 esRAGE 与 CVD 之间的关系不一致。为了确定 sRAGE 作为治疗心血管疾病的治疗靶点的潜在功能，需要进一步的研究来更好地理解 sRAGE 与 CVD 之间的关系。在这篇综述中，我们探讨了 sRAGE 在不同 CVD 中的潜在功能，强调了未解决的问题，并概述了进一步研究的可能性。
