长寿个体中可溶性晚期糖基化终产物受体异构体和晚期糖基化终产物的调节。

Modulation of soluble receptor for advanced glycation end products isoforms and advanced glycation end products in long-living individuals.

机构信息

Unit of Experimental Cardio-Oncology & Cardiovascular Aging, Centro Cardiologico Monzino-IRCCS, Milan, 20138, Italy.

Unit of Biostatistics, Centro Cardiologico Monzino-IRCCS, Milan, 20138, Italy.

出版信息

Biomark Med. 2021 Aug;15(11):785-796. doi: 10.2217/bmm-2020-0856. Epub 2021 Jul 8.

DOI:10.2217/bmm-2020-0856

PMID:34236256

Abstract

Circulating levels of soluble receptor for advanced glycation end products (sRAGE) and advanced glycation end products (AGEs) correlate with aging/cardiovascular risk, which is delayed in long-living individuals (LLIs). AGEs/sRAGE isoforms (cleaved RAGE [cRAGE] and secretory RAGE [esRAGE]) ratio is a valuable marker for disease risk. We evaluated circulating sRAGE isoforms, and AGEs in LLIs (n = 95; 90-105 years) and controls (n = 94; 11-89 years). cRAGE decreased with age in controls and further declined in LLIs. esRAGE increased in LLIs. AGEs rose with age in controls and decreased in LLIs that were characterized by a lower AGEs/sRAGE ratio. Notably, cRAGE and AGE/esRAGE ratio better discriminated controls from LLIs. circulating cRAGE could be considered a reliable marker of chronological age while esRAGE a protective factor for longevity.

摘要

循环中可溶性晚期糖基化终产物受体（sRAGE）和晚期糖基化终产物（AGEs）的水平与衰老/心血管风险相关，而在长寿个体（LLIs）中这种相关性会延迟。AGEs/sRAGE 同种型（切割型 RAGE [cRAGE] 和分泌型 RAGE [esRAGE]）比值是疾病风险的一个有价值的标志物。我们评估了循环 sRAGE 同种型和长寿个体（n=95；90-105 岁）和对照组（n=94；11-89 岁）中的 AGEs。在对照组中，cRAGE 随年龄增长而下降，而在 LLIs 中进一步下降。在 LLIs 中，esRAGE 增加。在对照组中，AGEs 随年龄增长而增加，而在以较低 AGEs/sRAGE 比值为特征的 LLIs 中则减少。值得注意的是，cRAGE 和 AGE/esRAGE 比值能更好地区分对照组和 LLIs。循环 cRAGE 可被视为衡量实际年龄的可靠标志物，而 esRAGE 是长寿的保护因素。