Danone Nutricia Research, Utrecht, the Netherlands.
Clinique et Maternité Sainte-Elisabeth, Namur, Belgium.
Am J Clin Nutr. 2024 Jan;119(1):87-99. doi: 10.1016/j.ajcnut.2023.10.017. Epub 2023 Nov 15.
Human milk comprises large fat globules enveloped by a native phospholipid membrane, whereas infant formulas contain small, protein-coated lipid droplets. Previous experimental studies indicated that mimicking the architecture of human milk lipid droplets in infant milk formula (IMF) alters lipid metabolism with lasting beneficial impact on later metabolic health.
To evaluate in a follow-up (FU) study of a randomized, controlled trial whether a Concept IMF with large, milk phospholipid-coated lipid droplets enriched with dairy lipids beneficially impacts long-term body mass index (BMI in kg/m) trajectories and blood pressure at school age.
Fully formula-fed infants were randomly assigned to Concept IMF (n = 115) or Control IMF with conventional, small lipid droplets containing vegetable oils (n = 108) for the first 4 mo of age. A group of 88 breastfed infants served as a reference. During FU, anthropometrics were collected at 1, 3, 4, and 5 y of age, and blood pressure only at the last visit.
Compared to Control, Concept group children had consistently lower mean BMI values during FU, with the most marked difference at 1 y of age (difference in means -0.71 kg/m, 95% confidence interval (CI): -1.13, -0.29; P = 0.001); mean values were close to the breastfed group (P > 0.05). Contrary, the mean BMI values of the Control group were higher compared with the breastfed group during FU from 1 to 5 y of age (differences in means from 0.59 to 0.96 kg/m, respectively; P < 0.02). At 5 y of age, the Concept group had a lower mean diastolic and arterial blood pressure compared with the Control group; -4.3mm Hg (95% CI: -7.3, -1.3; P = 0.005) and -3.7 mm Hg (95% CI: -6.5, -0.9; P = 0.01), respectively.
Early life feeding of an innovative IMF with large, milk phospholipid-coated lipid droplets enriched with dairy lipids results in a BMI trajectory closer to breastfed infants and a lower blood pressure at school age. This trial was registered at the Dutch Trial Register as NTR3683 and NTR5538.
人乳包含被天然磷脂膜包裹的大脂肪球，而婴儿配方奶粉则含有小的、蛋白质包裹的脂质滴。先前的实验研究表明，在婴儿配方奶粉中模拟人乳脂质滴的结构会改变脂质代谢，并对后期代谢健康产生持久的有益影响。
在一项随机对照试验的随访研究中评估，富含乳制品脂肪的具有大的、乳磷脂包裹的脂质滴的新概念配方奶粉（IMF）是否会对儿童期的体重指数（BMI，kg/m²）轨迹和血压产生有益影响。
完全配方奶喂养的婴儿在出生后 4 个月内被随机分配到新概念 IMF 组（n=115）或含有植物油的常规小脂质滴的对照 IMF 组（n=108）。88 名母乳喂养的婴儿作为参考组。在随访期间，在 1、3、4 和 5 岁时收集人体测量学数据，仅在最后一次就诊时测量血压。
与对照组相比，概念组儿童在随访期间的平均 BMI 值始终较低，1 岁时差异最显著（平均差值-0.71kg/m，95%置信区间（CI）：-1.13，-0.29；P=0.001）；与母乳喂养组接近（P＞0.05）。相反，在从 1 岁到 5 岁的随访期间，对照组的平均 BMI 值均高于母乳喂养组（差值分别为 0.59kg/m 至 0.96kg/m，P＜0.02）。在 5 岁时，概念组的舒张压和收缩压均低于对照组；-4.3mmHg（95%CI：-7.3，-1.3；P=0.005）和-3.7mmHg（95%CI：-6.5，-0.9；P=0.01）。
生命早期给予富含乳制品脂肪的创新型 IMF，其中含有大的、乳磷脂包裹的脂质滴，会导致 BMI 轨迹更接近母乳喂养的婴儿，且儿童期血压更低。该试验在荷兰临床试验注册中心注册，注册号为 NTR3683 和 NTR5538。
