Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) - Raebareli, Lucknow 226002, India.
Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, New South Wales 2007, Australia.
Curr Pharm Des. 2023;29(40):3206-3220. doi: 10.2174/0113816128263001231102053654.
Liposomes have gained a lot of interest for drug delivery applications, and some of these preparations have been commercialized. These are formulated with biocompatible components and can be used for delivering a wide range of payloads differing in aqueous solubility and molecular weight. Liposome-based delivery approaches are limited mainly by two factors: (a) poor dispersion stability, and (b) pre-mature leakage of payloads. In this review, we have discussed the stabilization of liposomal vesicles by their entrapment in hydrogels. Studies reveal that such hydrogels can maintain the structural integrity of liposomes. Release of liposomes from the hydrogel network can be modulated through careful screening of matrix former and degree of its cross-linking. Accordingly, we have reviewed the approaches of stabilizing liposomal vesicles through entrapment in hydrogels. Application of liposome-embedded hydrogels has been reviewed in context of localized drug delivery. Our discussion is focussed on the delivery of bioactives to the skin. Such an approach appears alluring from the standpoint of minimizing the undesirable distribution of payload(s) the systemic circulation and off-target sites.
脂质体在药物传递应用中引起了广泛关注，其中一些制剂已经商业化。这些制剂是用生物相容性成分制成的，可以用于传递各种不同水溶性和分子量的有效载荷。基于脂质体的传递方法主要受到两个因素的限制：(a) 分散稳定性差，(b) 有效载荷的过早泄漏。在这篇综述中，我们讨论了通过将脂质体囊泡包埋在水凝胶中来稳定脂质体。研究表明，这种水凝胶可以保持脂质体的结构完整性。通过仔细筛选基质形成剂及其交联程度，可以调节脂质体从水凝胶网络中的释放。因此，我们综述了通过包埋在水凝胶中来稳定脂质体囊泡的方法。我们还讨论了在局部药物传递中应用包埋脂质体的水凝胶。我们的讨论集中在将生物活性剂递送到皮肤的应用上。从最小化有效载荷（s）在全身循环和非靶部位的不良分布的角度来看，这种方法似乎很有吸引力。
