Agarwal Sangeet Kumar, Monga Uday, Chadha Shiv, Gupta Arushi, Dutta Vijay Bhushan
Head and Neck Oncosurgery, Sir Ganga Ram Hospital Sir Ganga Ram Hospital Marg, New Delhi, 110060 India.
ENT department, Sir Ganga Ram Hospital Sir Ganga Ram Hospital Marg, New Delhi, 110060 India.
Indian J Otolaryngol Head Neck Surg. 2023 Dec;75(4):3964-3966. doi: 10.1007/s12070-023-03987-9. Epub 2023 Jun 24.
Giant parathyroid adenoma (GPA) is a large tumor weighing more than 3.5 g but can weigh as much as 110 g as compared to parathyroid adenomas which usually weigh in the vicinity of 1 g and measure around 1-2 cm. These mainly present with primary hyperparathyroidism. We describe an interesting case and clinical course of a young woman with giant parathyroid adenoma. A 30-year-old Indian female presented with acute pancreatitis and acute kidney injury and was found to have hypercalcemia and hyperparathyroidism on further evaluation. Her physical examination revealed firm, non-tender, and mobile swelling of size 5 × 2 cm on the left side of her neck. USG neck showed a large heterogenous hypoechoic lesion in the left lower pole region of the left thyroid gland measuring 50 × 24 × 29 mm with a volume of 18 ccs. A parathyroid scan was performed using Tc Sesta MIBI tracer which was suggestive of a large adenoma in relation to the left lobe of the thyroid gland. She underwent minimally invasive parathyroidectomy with excision of left parathyroid adenoma under general anesthesia. Intraoperative frozen section confirmed the specimen to be parathyroid tissue. Her parathyroid hormone (PTH) level decreased from 1900 pg/ml in the pre-operative level to 242 pg/ml in the immediate postoperative period.
巨大甲状旁腺腺瘤（GPA）是一种重量超过3.5克的大肿瘤，但与通常重约1克、大小约1 - 2厘米的甲状旁腺腺瘤相比，其重量可达110克。这些肿瘤主要表现为原发性甲状旁腺功能亢进。我们描述了一名患有巨大甲状旁腺腺瘤的年轻女性的有趣病例及临床病程。一名30岁的印度女性因急性胰腺炎和急性肾损伤就诊，进一步检查发现有高钙血症和甲状旁腺功能亢进。体格检查发现其颈部左侧有一个质地坚硬、无压痛、可活动的5×2厘米大小的肿块。颈部超声检查显示左侧甲状腺左下极区域有一个大的不均匀低回声病变，大小为50×24×29毫米，体积为18立方厘米。使用锝 - 99m甲氧基异丁基异腈（Tc Sesta MIBI）示踪剂进行甲状旁腺扫描，提示甲状腺左叶有一个大腺瘤。她在全身麻醉下接受了微创甲状旁腺切除术，切除了左侧甲状旁腺腺瘤。术中冰冻切片证实标本为甲状旁腺组织。她的甲状旁腺激素（PTH）水平从术前的1900皮克/毫升降至术后即刻的242皮克/毫升。
