生化指标能否预测原发性甲状旁腺功能亢进症中腺瘤的重量？
Are biochemical values predictive of adenoma's weight in primary hyperparathyroidism?
作者信息
Hamidi Sepehr, Aslani Afshin, Nakhjavani Manouchehr, Pajouhi Mohammad, Hedayat Anushiravan, Kamalian Nasser
机构信息
School of Medicine, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
ANZ J Surg. 2006 Oct;76(10):882-5. doi: 10.1111/j.1445-2197.2006.03896.x.
BACKGROUND
Preoperative laboratory findings may carry some predictive value about the size of the abnormal parathyroid tissue that needs to be removed in primary hyperparathyroidism.
METHODS
In a retrospective study from 1988 to 2003, records of 71 patients with parathyroid adenoma were reviewed. The correlation between preoperative serum calcium, phosphate and parathyroid hormone (PTH) with adenoma's weight was analysed separately.
RESULTS
There was a significant correlation between preoperative serum PTH and calcium with adenoma's weight (P < 0.001 and P = 0.03, respectively). The correlation between preoperative serum phosphate and adenoma's weight was not significant (P = 0.1).
CONCLUSION
Preoperative PTH level cannot be used as a definite guide to the parathyroid adenoma's weight. Large parathyroid adenomas seem to secrete less PTH per unit weight than small adenomas. Calcium and phosphate do not seem to be of much value in predicting adenoma's weight in primary hyperparathyroidism.
背景
术前实验室检查结果可能对原发性甲状旁腺功能亢进症中需要切除的异常甲状旁腺组织的大小具有一定的预测价值。
方法
在一项对1988年至2003年期间71例甲状旁腺腺瘤患者的回顾性研究中，对其记录进行了复查。分别分析了术前血清钙、磷和甲状旁腺激素（PTH）与腺瘤重量之间的相关性。
结果
术前血清PTH和钙与腺瘤重量之间存在显著相关性（分别为P < 0.001和P = 0.03）。术前血清磷与腺瘤重量之间的相关性不显著（P = 0.1）。
结论
术前PTH水平不能作为甲状旁腺腺瘤重量的明确指导。大的甲状旁腺腺瘤似乎每单位重量分泌的PTH比小腺瘤少。钙和磷在预测原发性甲状旁腺功能亢进症腺瘤重量方面似乎价值不大。
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