Girardi Fábio Muradás, de Carvalho Neto Antônio Augusto, Martins Manoela Domingues
Integrated Oncology Center of Ana Nery Hospital, Pereira da Cunha Street, 209, 96835090 Santa Cruz do Sul, Brazil.
Objetiva Pathologic Laboratory, Santa Cruz do Sul, RS Brazil.
Indian J Otolaryngol Head Neck Surg. 2023 Dec;75(4):2993-2997. doi: 10.1007/s12070-023-03919-7. Epub 2023 Jun 2.
Surgical resection is the gold standard treatment for basal cell carcinomas, although there is literature supporting cryotherapy for low-risk cases. Our aim was to compare the histopathological aspects of recurrent postcryotherapy head and neck cutaneous BCC with de novo tumors, using a case-control study. 51 Recurrent postcryotherapy cases were selected between January 2017 and December 2021 and compared to 132 controls filtered from a consecutive series of de novo head and neck cutaneous BCC operated between January and December 2021. Aggressive variants, multifocality, invasion beyond adipose tissue and higher Clark levels were associated with recurrent cases on multivariate analysis. Previous cryotherapy treatment may have contributed to an increased risk of more aggressive recurrent disease and caution using this treatment modality is advised.
The online version contains supplementary material available at 10.1007/s12070-023-03919-7.
手术切除是基底细胞癌的金标准治疗方法，尽管有文献支持对低风险病例采用冷冻疗法。我们的目的是通过病例对照研究，比较冷冻治疗后复发性头颈部皮肤基底细胞癌与原发性肿瘤的组织病理学特征。在2017年1月至2021年12月期间选择了51例冷冻治疗后复发的病例，并与从2021年1月至12月连续进行的原发性头颈部皮肤基底细胞癌手术系列中筛选出的132例对照进行比较。多因素分析显示，侵袭性变体、多灶性、脂肪组织外侵犯和更高的克拉克分级与复发病例相关。先前的冷冻治疗可能导致更具侵袭性的复发性疾病风险增加，建议谨慎使用这种治疗方式。
在线版本包含可在10.1007/s12070-023-03919-7获取的补充材料。
