Roane D S, Porter J R
Physiol Behav. 1986;38(2):215-8. doi: 10.1016/0031-9384(86)90156-3.
Previous research indicates a possible interrelationship between the endogenous opioids (EO), nociception and food-intake. We therefore considered the hyperphagic obese Zucker rat a good candidate for abnormal responses to nociceptive stimuli. Pairs of lean and obese sisters were tested for latency of response to nociceptive stimuli by tail-flick and tail-pinch methods. Obese rats exhibited shorter latencies in each test, (tail-flick, p less than 0.05 and tail-pinch, p less than 0.001). Dose/response curves for morphine analgesia indicate that morphine is less potent in obese than in lean rats (ED50's = 4.87 +/- 0.62 mg/kg and 3.12 +/- 0.41 mg/kg respectively, p less than 0.05). These data suggest a defect in the EO systems of obese Zucker rats.
先前的研究表明内源性阿片类物质（EO）、痛觉感受与食物摄入之间可能存在相互关系。因此，我们认为食欲亢进的肥胖 Zucker 大鼠是对伤害性刺激反应异常的良好候选对象。通过甩尾和夹尾方法，对瘦型和肥胖型姐妹大鼠进行配对测试，以检测其对伤害性刺激的反应潜伏期。在每次测试中，肥胖大鼠的潜伏期均较短（甩尾，p<0.05；夹尾，p<0.001）。吗啡镇痛的剂量/反应曲线表明，吗啡对肥胖大鼠的效力低于对瘦型大鼠的效力（ED50 分别为 4.87±0.62mg/kg 和 3.12±0.41mg/kg，p<0.05）。这些数据表明肥胖 Zucker 大鼠的 EO 系统存在缺陷。
