Refinetti R, Carlisle H J
Physiol Behav. 1986;38(2):219-28. doi: 10.1016/0031-9384(86)90157-5.
The effects of bilateral lesions in the lateral hypothalamus (LH) of the rat on several thermoregulatory and non-thermoregulatory variables were studied. In agreement with the literature, a reduction in food and water intake and in body mass were observed in the experimental animals but not in the operated controls. Rectal temperature and metabolism increased for a few hours after the lesion, decreased below pre-lesion level for a day or two, and finally returned to baseline level. The increase in rectal temperature during a 1-hr exposure to 5 degrees C was accentuated in the control but not in the experimental subjects. An improvement in operant thermoregulatory behavior, measured by nose-poke and lever-press responses, was observed in most LH-lesioned animals. Thermal preference in a gradient, two measures of general activity, and light avoidance were not affected by the lesions. The post-lesion improvement in operant thermoregulatory behavior does not support the view of the LH as a necessary locus for the integration of behavioral thermoregulatory responses.
研究了大鼠双侧下丘脑外侧区（LH）损伤对几个体温调节和非体温调节变量的影响。与文献一致，在实验动物中观察到食物和水摄入量以及体重减少，但在假手术对照组中未观察到。损伤后几小时直肠温度和代谢增加，在一两天内降至损伤前水平以下，最终恢复到基线水平。在1小时暴露于5摄氏度期间，对照组直肠温度升高更为明显，而实验对象则不然。在大多数LH损伤的动物中，通过鼻戳和杠杆按压反应测量的操作性体温调节行为有所改善。梯度中的热偏好、两种一般活动量度以及避光不受损伤影响。损伤后操作性体温调节行为的改善并不支持将LH视为行为体温调节反应整合的必要位点的观点。
