Corbett S W, Wilterdink E J, Keesey R E
Physiol Behav. 1985 Dec;35(6):971-7. doi: 10.1016/0031-9384(85)90268-9.
Rats maintaining stable, reduced body weights following lateral hypothalamic (LH) lesions were given either ad lib amounts of a palatable liquid diet or restricted amounts of a hydrated chow diet. The palatable diet produced weight gains while the diet restriction led to weight reductions in both LH- and sham-lesioned rats. Body composition analysis indicated that these changes in body mass were accounted for largely by changes in carcass fat. Resting oxygen consumption (expressed relative to body weight raised to the 3/4 power) was altered by both dietary regimens. Resting oxygen consumption in sham-lesioned rats increased by 5% following overfeeding and decreased by 13% following food restriction. LH-lesioned rats made similar responses to these dietary challenges. Overfed LH-lesioned rats increased their rate of resting oxygen consumption by 11%. Underfed LH-lesioned rats decreased oxygen consumption by 11%. These findings provide further evidence that rats with LH lesions defend a reduced level of body weight. The changes in energy expenditure that mitigate weight change in sham-lesioned animals are also present in LH-lesioned rats. In the latter, however, these adjustments serve to stabilize body weight at a lower level.
对下丘脑外侧（LH）损伤后体重保持稳定下降的大鼠，给予随意量的可口液体饮食或限量的含水普通饲料。可口饮食使体重增加，而饮食限制导致LH损伤和假手术损伤大鼠体重均下降。身体成分分析表明，体重的这些变化主要是由胴体脂肪的变化引起的。两种饮食方案均改变了静息耗氧量（相对于体重的3/4次方表示）。假手术损伤大鼠在过量喂食后静息耗氧量增加5%，在食物限制后降低13%。LH损伤大鼠对这些饮食挑战有类似反应。过量喂食的LH损伤大鼠静息耗氧量增加11%。喂食不足的LH损伤大鼠耗氧量降低11%。这些发现进一步证明，LH损伤的大鼠维持较低的体重水平。减轻假手术损伤动物体重变化的能量消耗变化在LH损伤大鼠中也存在。然而，在后者中，这些调节作用是使体重稳定在较低水平。
