Scallet A C, McLaughlin C L, Della-Fera M A, Baile C A
Physiol Behav. 1986;38(2):295-7. doi: 10.1016/0031-9384(86)90166-6.
Clonidine, an alpha-noradrenergic agonist, has had inconsistent effects when administered peripherally in previous studies of feeding behavior. The present experiment was undertaken to evaluate clonidine using an operant feeding paradigm (continuous reinforcement schedule) to provide detailed data on the time course of its effects. Over an entire four-hour session, all doses of clonidine tested (25, 50, or 100 micrograms/kg) increased bar-pressing. The 50 micrograms/kg dose was most effective. An examination of the time course of responding revealed that the initial effect of clonidine was to decrease responses with the duration and magnitude of the decrease directly proportional to dose. However, clonidine also prolonged a phase of steady responding for food once the animals resumed bar-pressing, resulting in a net increase of food intake. Future investigations of clonidine should take into account the effects of increasing dose on delayed onset of feeding.
可乐定是一种α-去甲肾上腺素能激动剂，在以往关于摄食行为的外周给药研究中，其效果并不一致。本实验采用操作性摄食范式（连续强化程序）对可乐定进行评估，以提供其作用时间过程的详细数据。在整个四小时的实验过程中，所有测试剂量的可乐定（25、50或100微克/千克）均增加了压杆次数。50微克/千克的剂量最为有效。对反应时间过程的检查显示，可乐定的初始作用是减少反应，减少的持续时间和幅度与剂量成正比。然而，一旦动物恢复压杆，可乐定也会延长对食物的稳定反应阶段，导致食物摄入量净增加。未来对可乐定的研究应考虑剂量增加对摄食延迟发作的影响。
