Asin K E, Wirtshafter D
Psychopharmacology (Berl). 1985;85(3):383-5. doi: 10.1007/BF00428206.
The possibility that the alpha-adrenergic agonist clonidine can act as a reinforcing agent was investigated using the conditioned place preference paradigm. Using two different variants of this method we were able to demonstrate reinforcing properties of clonidine at doses of 200 and 400 micrograms/kg. These results are consistent with those obtained by other investigators using the self-administration technique, and support the view that adrenergic mechanisms may be involved in reinforcement.
使用条件性位置偏爱范式研究了α-肾上腺素能激动剂可乐定作为强化剂的可能性。通过该方法的两种不同变体，我们能够证明可乐定在200和400微克/千克剂量下具有强化特性。这些结果与其他研究人员使用自我给药技术获得的结果一致，并支持肾上腺素能机制可能参与强化作用的观点。
