Salari Nader, Moradi Mona, Hosseinian-Far Amin, Khodayari Yassaman, Mohammadi Masoud
Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
J Diabetes Metab Disord. 2023 Jul 28;22(2):1011-1019. doi: 10.1007/s40200-023-01267-5. eCollection 2023 Dec.
Sexual dysfunction is a common disorder among women, especially during menopause. Metabolic syndrome is a multifactorial disease that, according to previous studies, there is a relationship between the metabolic syndrome and sexual dysfunction among women. The aim of this systematic review and meta-analysis is to obtain the prevalence of Female Sexual Dysfunction (FSD) among women with metabolic syndrome, and to analyze available related evidence.
In this systematic review and meta-analysis, the keywords of MeSH, female sexual dysfunction, FSD, metabolic syndrome were searched in PubMed, Web of Science, Scopus, Science Direct and Google Scholar. The searches were conducted without a lower time limit and until May 2022.
The prevalence of FSD among women with metabolic syndrome was found to be 39.3% (95% CI: 28.3-51.5). In the subgroup analysis and in the review of 4 studies, the prevalence of sexual dysfunction in postmenopausal women with metabolic syndrome was 49.8% (95% CI: 26.1-73.6). Analyzing the results of the meta-regression test in examining the effect of the three factors of sample size, year of the study, age, and BMI of the patients on the heterogeneity of the meta-analysis, showed that with the increase of the sample size, the prevalence of sexual dysfunction among women with metabolic syndrome decreases ( < 0.05). Moreover, the prevalence of sexual dysfunction among women with metabolic syndrome increases ( < 0.05) with the increase in the years of conducting studies and the mean of age of women with metabolic syndrome. Also, with increasing mean of BMI of female patients with metabolic syndrome, the prevalence of sexual dysfunction in these women also increases ( < 0.05).
Female sexual dysfunction is a global health problem that can affect women's life to a great extent. Metabolic syndrome, which is a set of factors such as obesity, high blood pressure, and diabetes, affects sexual dysfunction in women. From this study, it can be concluded that there is a close relationship between metabolic syndrome and female sexual dysfunction.
性功能障碍是女性中的常见疾病，尤其是在绝经期间。代谢综合征是一种多因素疾病，根据以往研究，女性的代谢综合征与性功能障碍之间存在关联。本系统评价和荟萃分析的目的是得出代谢综合征女性中女性性功能障碍（FSD）的患病率，并分析现有相关证据。
在本系统评价和荟萃分析中，在PubMed、科学网、Scopus、Science Direct和谷歌学术中检索了医学主题词（MeSH）的关键词、女性性功能障碍、FSD、代谢综合征。检索没有时间下限，截至2022年5月。
发现代谢综合征女性中FSD的患病率为39.3%（95%置信区间：28.3 - 51.5）。在亚组分析以及对4项研究的综述中，患有代谢综合征的绝经后女性性功能障碍的患病率为49.8%（95%置信区间：26.1 - 73.6）。在检查样本量、研究年份、患者年龄和体重指数这三个因素对荟萃分析异质性的影响时，对荟萃回归测试结果进行分析表明，随着样本量的增加，代谢综合征女性中性功能障碍的患病率降低（<0.05）。此外，随着研究年份的增加以及代谢综合征女性平均年龄的增加，代谢综合征女性中性功能障碍的患病率增加（<0.05）。同样，随着患有代谢综合征女性患者平均体重指数的增加，这些女性性功能障碍的患病率也增加（<0.05）。
女性性功能障碍是一个全球性的健康问题，会在很大程度上影响女性的生活。代谢综合征是一组如肥胖、高血压和糖尿病等因素，会影响女性的性功能障碍。从本研究可以得出结论，代谢综合征与女性性功能障碍之间存在密切关系。
