Rösch J, Uchida B T, Putnam J S, Buschman R W, Law R D, Hershey A L
Radiology. 1987 Feb;162(2):481-5. doi: 10.1148/radiology.162.2.3797662.
Original Gianturco expandable stents and their modifications were used to create an experimental intrahepatic portacaval anastomosis (EIPCA) in 30 young domestic swine without portal hypertension. The study focused on the design of a suitable stent, the technique of its application, and the evaluation of short-term patency of the EIPCA. A stent with a 2.5-cm-long body and wire skirts on both ends was most suitable for EIPCA creation. Well-positioned stents shunted most of the portal blood in the inferior vena cava circulation and remained patent for 4-6 weeks. Ingrowth of liver parenchyma and abundant proliferation of the intima and connective tissue inside the stent lumen in these rapidly growing animals gradually decreased EIPCA patency, and thrombus formation with diminished blood flow closed them completely.
使用原始的Gianturco可扩张支架及其改良型,在30头无门静脉高压的幼年家猪身上建立了实验性肝内门腔静脉吻合术(EIPCA)。该研究重点在于合适支架的设计、其应用技术以及EIPCA短期通畅性的评估。一种主体长度为2.5厘米且两端带有金属丝裙边的支架最适合用于创建EIPCA。定位良好的支架使大部分门静脉血分流至下腔静脉循环中,并在4至6周内保持通畅。在这些生长迅速的动物中,肝实质向内生长以及支架腔内内膜和结缔组织的大量增生逐渐降低了EIPCA的通畅性,血栓形成以及血流减少最终使其完全闭塞。