Qidwai Tabish
Faculty of Biotechnology, Shri Ramswaroop Memorial University, Lucknow Deva Road, Uttar Pradesh 225003, India.
Cytokine. 2024 Jan;173:156420. doi: 10.1016/j.cyto.2023.156420. Epub 2023 Nov 15.
Infectious diseases are affecting the people worldwide. Mostly, infectious agents activate excessive production of cytokines so called cytokine storm. Among the infectious diseases COVID-19 is one of the deadliest diseases affecting individuals all over the world, moreover, Plasmodium falciparum malaria and HIV are major killers. An excessive pro-inflammatory response is one of the major causes of pathological conditions in these diseases. It is important to investigate the pathophysiology in the infectious diseases such as COVID-19, malaria and HIV as there is no concrete therapy against them so far. Exploration of excessive pro-inflammation could be important for therapeutic intervention. In this article, an attempt has been made to analyze the pathological conditions arise due to excessive inflammatory response in COVID-19, malaria and other infectious diseases. Targeting excessive pro-inflammatory response/cytokine storm in infectious diseases could be a useful strategy.
传染病正在影响全世界的人们。大多数情况下，感染因子会激活细胞因子的过度产生，即所谓的细胞因子风暴。在传染病中，新冠病毒病是影响全球个人的最致命疾病之一，此外，恶性疟原虫疟疾和艾滋病病毒也是主要杀手。过度的促炎反应是这些疾病病理状况的主要原因之一。研究新冠病毒病、疟疾和艾滋病病毒等传染病的病理生理学很重要，因为目前尚无针对它们的具体疗法。探索过度的促炎反应可能对治疗干预很重要。在本文中，已尝试分析新冠病毒病、疟疾和其他传染病中因过度炎症反应而出现的病理状况。针对传染病中过度的促炎反应/细胞因子风暴可能是一种有用的策略。
