Larsson Birgitta Jakobsson, Nordin Karin, Nygren Ingela
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden; Department of Neurology, Uppsala University Hospital, Uppsala, Sweden.
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
J Neurol Sci. 2023 Dec 15;455:122780. doi: 10.1016/j.jns.2023.122780. Epub 2023 Nov 6.
The aim of this study was to describe the presence of anxiety and depression among patients with Amyotrophic Lateral Sclerosis (ALS) and their relatives from diagnosis and during the disease progression. An additional aim was to explore if the patient's physical function correlated with the patients' or relatives' anxiety and depression.
A prospective and longitudinal study, including 33 patients with ALS and their relatives who filled out the Hospital Anxiety and Depression Scale (HADS) at the time of diagnosis and over a period of two years. The patient's physical function was measured with the revised Amyotrophic Lateral Sclerosis Functional and Rating Scale (ALS FRS-R).
The results showed that many patients (45%) and relatives (58%) had symptoms of anxiety and that 13% of the patients and 29% of the relatives had symptoms of depression soon after the patient had been diagnosed with ALS. The prevalence of anxiety decreased over time in the group of patients but remained stable in the group of relatives. Relatives had more symptoms of anxiety compared to patients. There was a correlation between the patient's physical function and HADS in the group of relatives; however, no correlation was found in the group of patients.
The results showed that many patients and relatives suffered from symptoms of anxiety quite soon after their diagnosis, and that many relatives had symptoms of anxiety during the disease trajectory. This highlights the need to continuously measure patients' anxiety/depression level but also to pay attention to symptoms among relatives.
本研究旨在描述肌萎缩侧索硬化症（ALS）患者及其亲属从诊断开始及疾病进展过程中焦虑和抑郁的情况。另一个目的是探讨患者的身体功能是否与患者或亲属的焦虑和抑郁相关。
一项前瞻性纵向研究，纳入33例ALS患者及其亲属，他们在诊断时及两年期间填写了医院焦虑抑郁量表（HADS）。患者的身体功能用修订的肌萎缩侧索硬化症功能和评定量表（ALS FRS-R）进行测量。
结果显示，许多患者（45%）和亲属（58%）有焦虑症状，在患者被诊断为ALS后不久，13%的患者和29%的亲属有抑郁症状。患者组中焦虑的患病率随时间下降，但亲属组中保持稳定。与患者相比，亲属有更多的焦虑症状。亲属组中患者的身体功能与HADS之间存在相关性；然而，在患者组中未发现相关性。
结果表明，许多患者和亲属在诊断后不久就出现焦虑症状，并且许多亲属在疾病发展过程中也有焦虑症状。这突出了持续测量患者焦虑/抑郁水平的必要性，同时也需要关注亲属的症状。
