Georgieva Milena, Xenodochidis Charilaos, Krasteva Natalia
Institute of Molecular Biology "Acad. Roumen Tsanev", Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Exp Gerontol. 2023 Dec;184:112334. doi: 10.1016/j.exger.2023.112334. Epub 2023 Nov 25.
Recent scientific interest has been directed towards age-related diseases, driven by the significant increase in global life expectancy and the growing population of individuals aged 65 and above. The ageing process encompasses various biological, physiological, environmental, psychological, behavioural, and social changes, leading to an augmented susceptibility to chronic illnesses. Cardiovascular, neurological, musculoskeletal, liver and oncological diseases are prevalent in the elderly. Moreover, ageing individuals demonstrate reduced regenerative capacity and decreased tolerance towards therapeutic interventions, including organ transplantation. Liver diseases, such as non-alcoholic fatty liver disease, alcoholic liver disease, hepatitis, fibrosis, and cirrhosis, have emerged as significant public health concerns. Paradoxically, these conditions remain underestimated despite their substantial global impact. Age-related factors are closely associated with the severity and unfavorable prognosis of various liver diseases, warranting further investigation to enhance clinical management and develop novel therapeutic strategies. This comprehensive review focuses specifically on age-related liver diseases, their treatment strategies, and contemporary practices. It provides a detailed account of the global burden, types, molecular mechanisms, and epigenetic alterations underlying these liver pathologies.
近期，受全球预期寿命显著增加以及65岁及以上人口不断增长的推动，科学界的兴趣已转向与年龄相关的疾病。衰老过程涵盖各种生物、生理、环境、心理、行为和社会变化，导致对慢性病的易感性增加。心血管疾病、神经疾病、肌肉骨骼疾病、肝脏疾病和肿瘤疾病在老年人中很常见。此外，老年人的再生能力下降，对包括器官移植在内的治疗干预的耐受性降低。肝脏疾病，如非酒精性脂肪性肝病、酒精性肝病、肝炎、纤维化和肝硬化，已成为重大的公共卫生问题。矛盾的是，尽管这些疾病对全球有重大影响，但仍未得到充分重视。与年龄相关的因素与各种肝脏疾病的严重程度和不良预后密切相关，需要进一步研究以加强临床管理并制定新的治疗策略。这篇综述特别关注与年龄相关的肝脏疾病、其治疗策略和当代实践。它详细阐述了这些肝脏疾病的全球负担、类型、分子机制和表观遗传改变。
