Montanari Martina, Mercuri Nicola Biagio, Martella Giuseppina
Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Laboratory of Neurophysiology and Plasticity, IRCCS Fondazione Santa Lucia, 00179 Rome, Italy.
Int J Mol Sci. 2024 Dec 26;26(1):122. doi: 10.3390/ijms26010122.
One of the most pressing challenges facing society today is the rising prevalence of physical and cognitive frailty. This geriatric condition makes older adults more vulnerable to disability, illness, and a heightened risk of mortality. In this scenario, Parkinson's disease (PD) and geriatric frailty, which share several common characteristics, are becoming increasingly prevalent worldwide, underscoring the urgent need for innovative strategies. Nutraceuticals are naturally occurring bioactive compounds contained in foods, offering health benefits over and above essential nutrition. By examining the literature from the past decade, this review highlights how nutraceuticals can act as complementary therapies, addressing key processes, such as oxidative stress, inflammation, and neuroprotection. Notably, the antioxidant action of nutraceuticals appears particularly beneficial in regard to PD and geriatric frailty. For instance, antioxidant-rich nutraceuticals may mitigate the oxidative damage linked to levodopa therapy in PD, potentially reducing the side effects and enhancing treatment sustainability. Similarly, the antioxidant effects of nutraceuticals may amplify the benefits of physical activity, enhancing muscle function, cognitive health, and resilience, thereby reducing the risk of frailty. This review proposes a holistic approach integrating nutraceuticals with exercise, pharmacotherapy, and lifestyle adjustments. It promises to transform the management of ARD, prolong life, and improve the quality of life and well-being of older people.
当今社会面临的最紧迫挑战之一是身体和认知衰弱的患病率不断上升。这种老年疾病使老年人更容易出现残疾、患病，且死亡风险更高。在这种情况下，帕金森病（PD）和老年衰弱有几个共同特征，在全球范围内日益普遍，凸显了对创新策略的迫切需求。营养保健品是食物中含有的天然生物活性化合物，除了提供基本营养外，还具有健康益处。通过回顾过去十年的文献，本综述强调了营养保健品如何作为辅助疗法，针对氧化应激、炎症和神经保护等关键过程发挥作用。值得注意的是，营养保健品的抗氧化作用在PD和老年衰弱方面似乎特别有益。例如，富含抗氧化剂的营养保健品可能减轻与PD左旋多巴治疗相关的氧化损伤，潜在地减少副作用并提高治疗的可持续性。同样，营养保健品的抗氧化作用可能会增强体育活动的益处，改善肌肉功能、认知健康和恢复力，从而降低衰弱风险。本综述提出了一种将营养保健品与运动、药物治疗和生活方式调整相结合的整体方法。它有望改变ARD的管理方式，延长寿命，并改善老年人的生活质量和幸福感。
