Al-Meshal I A
Res Commun Chem Pathol Pharmacol. 1986 Oct;54(1):129-32.
Physical characteristics, chemical constituents and biological activities of the volatile oil of Ducrosia ismaelis Asch. have been studied. It is a light yellow volatile liquid with a strong aromatic odour and a specific gravity of 0.9573. IR, NMR and GLC spectrometry studies revealed the presence of free alcohols, alkenes and highly conjugated alkenes, aromatic functions, alicyclic structures and cyclic ketones. The pharmacological studies show a highly significant and dose dependent central nervous system depressant and marked neuromuscular blocking actions. Experiments on smooth muscles and heart show a parasympatholytic activity. It also exhibits significant antimicrobial activity against Staphylococcus aureus, Bacillus subtilis and Candida albicans. Further studies are being undertaken to find out its mechanism of pharmacological actions and to identify the active principle(s) responsible for those effects.
对伊斯梅尔氏杜克罗草（Ducrosia ismaelis Asch.）挥发油的物理特性、化学成分及生物活性进行了研究。它是一种浅黄色挥发性液体，具有强烈的芳香气味，比重为0.9573。红外光谱（IR）、核磁共振（NMR）和气相色谱（GLC）光谱研究表明，其中存在游离醇、烯烃、高度共轭烯烃、芳香官能团、脂环结构和环状酮。药理研究显示出高度显著且剂量依赖性的中枢神经系统抑制作用以及明显的神经肌肉阻滞作用。对平滑肌和心脏的实验表明具有抗副交感神经活性。它对金黄色葡萄球菌、枯草芽孢杆菌和白色念珠菌也表现出显著的抗菌活性。正在进行进一步研究以找出其药理作用机制，并确定产生这些作用的活性成分。
