spp., Rare Plants with Promising Phytochemical and Pharmacological Characteristics: An Updated Review.

The rare genus (Apiaceae family) consists of six species, which are mainly native to Asia, specifically to Iran and Iraq. The aerial parts of as the most common species, have been traditionally consumed to relieve headache, backache and colic pain, and have also been used as an anxiolytic, an antidepressant, and for treating insomnia. The antispasmodic and carminative effects of , and the analgesic activity of , along with the insecticidal activities and use as a remedy of skin infections of , have been previously documented. Among the 49 non-volatile secondary metabolites identified from and , 17 linear furanocoumarins and 8 flavonoids have been characterized. The essential oil compositions of four species, including , , and , have been analyzed, whereby aldehyde hydrocarbons, including decanal (10.1‒74.0%) and dodecanal (7.2‒33.41%), and α-pinene (4.0‒70.3%), were identified as the main aroma constituents. From the species of the genus, the bioactivities of , as well as , and , have been previously investigated. Except one clinical trial, all the pharmacological data are derived from preclinical tests, predominantly focusing on antimicrobial, antioxidant, antiproliferative and cytotoxic activities in vitro, and neuroprotective, antidiabetic and analgesic effects in vivo. Considering the vast ethnobotanical uses of the plants in Iranian folk medicine, the phytochemical and pharmacological analysis of un-investigated species might be promising. Furthermore, due to extensive consumption of the genus, more scientific data are needed to support the safety and efficacy of these plants.