Biology Department, Université de Moncton, Moncton, New Brunswick E1A 3E9, Canada.
Biology Department, Université de Moncton, Moncton, New Brunswick E1A 3E9, Canada.
Reprod Biol. 2023 Dec;23(4):100823. doi: 10.1016/j.repbio.2023.100823. Epub 2023 Nov 17.
Members of the SRY-related box (SOX) subfamily D (SoxD) of transcription factors are well conserved among vertebrate species and play important roles in different stages of male reproductive development. In mammals, the SoxD subfamily contains three members: SOX5, SOX6 and SOX13. Here, we describe their implications in testicular development and spermatogenesis, contributing to fertility. We also cover the mechanisms of action of SoxD transcription factors in gene regulation throughout male development. The specificity of activation of target genes by SoxD members depends, in part, on their post-translational modifications and interactions with other partners. Sperm production in adult males requires the coordination in the regulation of gene expression by different members of the SoxD subfamily of transcription factors in the testis. Specifically, the regulation of genes promoting adequate spermatogenesis by SoxD members is discussed in comparison between species.
Sry 相关盒 (SOX) 转录因子亚家族 D (SoxD) 的成员在脊椎动物物种中高度保守，在雄性生殖发育的不同阶段发挥重要作用。在哺乳动物中，SoxD 亚家族包含三个成员：SOX5、SOX6 和 SOX13。在这里，我们描述了它们在睾丸发育和精子发生中的作用，这有助于生育。我们还介绍了 SoxD 转录因子在整个雄性发育过程中基因调控的作用机制。SoxD 成员对靶基因的激活特异性部分取决于它们的翻译后修饰和与其他伴侣的相互作用。成年雄性精子的产生需要不同 SoxD 转录因子亚家族成员在睾丸中协调调控基因表达。具体而言，我们比较了不同物种 SoxD 成员对促进精子发生的基因的调控。
