Department of Neurology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi Province 030000, China.
Department of Neurology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi Province 030000, China.
Brain Res Bull. 2023 Dec;205:110820. doi: 10.1016/j.brainresbull.2023.110820. Epub 2023 Nov 17.
Transforming growth factor-β1 (TGF-β1), a multifunctional cytokine, plays a pivotal role in synaptic formation, plasticity, and neurovascular unit regulation. This review highlights TGF-β1's potential impact on cognitive function, particularly in the context of neurodegenerative disorders. However, despite the growing body of evidence, a comprehensive understanding of TGF-β1's precise role remains elusive. Further research is essential to unravel the complex mechanisms through which TGF-β1 influences cognitive function and to explore therapeutic avenues for targeting TGF-β1 in neurodegenerative conditions. This investigation sheds light on TGF-β1's contribution to cognitive function and offers prospects for innovative treatments and interventions. This review delves into the intricate relationship between TGF-β1 and cognitive function.
转化生长因子-β1（TGF-β1）是一种多功能细胞因子，在突触形成、可塑性和神经血管单元调节中发挥关键作用。本综述强调了 TGF-β1 对认知功能的潜在影响，特别是在神经退行性疾病的背景下。然而，尽管有越来越多的证据，但 TGF-β1 的确切作用仍难以捉摸。进一步的研究对于揭示 TGF-β1 影响认知功能的复杂机制以及探索针对神经退行性疾病中 TGF-β1 的治疗途径至关重要。这项研究阐明了 TGF-β1 对认知功能的贡献，并为创新治疗和干预提供了前景。本综述深入探讨了 TGF-β1 与认知功能之间的复杂关系。
