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Brca1 Mouse Models: Functional Insights and Therapeutic Opportunities.
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2
The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans.
Oncogene. 2002 Dec 16;21(58):8994-9007. doi: 10.1038/sj.onc.1206177.
3
A novel model to characterize structure and function of BRCA1.
Cell Biol Int. 2018 Jan;42(1):34-44. doi: 10.1002/cbin.10846. Epub 2017 Oct 25.
4
The role of BRCA1 in DNA double-strand repair: past and present.
Exp Cell Res. 2013 Mar 10;319(5):575-87. doi: 10.1016/j.yexcr.2012.11.013. Epub 2012 Nov 29.
6
Links between genome integrity and BRCA1 tumor suppression.
Trends Biochem Sci. 2012 Oct;37(10):418-24. doi: 10.1016/j.tibs.2012.06.007. Epub 2012 Jul 24.
8
Tumorigenesis in mice carrying a truncating Brca1 mutation.
Genes Dev. 2001 May 15;15(10):1188-93. doi: 10.1101/gad.879201.
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Improved Therapeutic Window in -mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition.
Mol Cancer Ther. 2019 Jan;18(1):89-99. doi: 10.1158/1535-7163.MCT-18-0314. Epub 2018 Oct 23.
10
PALB2 is an integral component of the BRCA complex required for homologous recombination repair.
Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7155-60. doi: 10.1073/pnas.0811159106. Epub 2009 Apr 15.

引用本文的文献

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PALB2 and 53BP1 govern post-resection homologous recombination DNA repair.
Mol Cell. 2025 Jul 31. doi: 10.1016/j.molcel.2025.07.003.
2
New twist on BRCA1-mediated DNA recombination repair and tumor suppression.
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本文引用的文献

1
Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities.
Nat Commun. 2023 Nov 24;14(1):7714. doi: 10.1038/s41467-023-43446-1.
2
Crucial roles of the BRCA1-BARD1 E3 ubiquitin ligase activity in homology-directed DNA repair.
Mol Cell. 2023 Oct 19;83(20):3679-3691.e8. doi: 10.1016/j.molcel.2023.09.015. Epub 2023 Oct 4.
4
RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage.
Nat Commun. 2021 Aug 18;12(1):5016. doi: 10.1038/s41467-021-25346-4.
5
BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination.
Nature. 2021 Aug;596(7872):433-437. doi: 10.1038/s41586-021-03776-w. Epub 2021 Jul 28.
6
ATR/ATM-Mediated Phosphorylation of BRCA1 T1394 Promotes Homologous Recombinational Repair and G-M Checkpoint Maintenance.
Cancer Res. 2021 Sep 15;81(18):4676-4684. doi: 10.1158/0008-5472.CAN-20-2723. Epub 2021 Jul 23.
7
A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.
Nat Cancer. 2021 Jun;2(6):598-610. doi: 10.1038/s43018-021-00203-x. Epub 2021 Jun 17.
8
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.
Nat Commun. 2021 Jun 17;12(1):3636. doi: 10.1038/s41467-021-23463-8.
9
Replication Gaps Underlie BRCA Deficiency and Therapy Response.
Cancer Res. 2021 Mar 1;81(5):1388-1397. doi: 10.1158/0008-5472.CAN-20-1602. Epub 2020 Nov 12.
10
Ablation of the Brca1-Palb2 Interaction Phenocopies Fanconi Anemia in Mice.
Cancer Res. 2020 Oct 1;80(19):4172-4184. doi: 10.1158/0008-5472.CAN-20-0486. Epub 2020 Jul 30.

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