Nuclear Dynamics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Nuclear Dynamics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
J Mol Biol. 2024 Jan 1;436(1):168372. doi: 10.1016/j.jmb.2023.168372. Epub 2023 Nov 17.
Brca1 mouse models were first reported in the mid-1990's shortly after cloning the human gene. Since then, many mouse models with a range of mutations have been generated, some mimic patient mutations, others are designed to probe specific protein domains and functions. In this review, we discuss early and recent studies using engineered Brca1 mouse alleles, and their implications for understanding Brca1 protein function in the context of DNA repair, tumorigenesis, and anti-cancer therapeutics.
Brca1 小鼠模型最早是在 20 世纪 90 年代中期克隆人类基因后不久被报道的。此后，许多带有多种突变的小鼠模型被构建出来，其中一些模拟了患者的突变，而另一些则旨在探究特定的蛋白质结构域和功能。在这篇综述中，我们讨论了早期和近期使用工程化 Brca1 小鼠等位基因的研究，并探讨了这些研究对理解 Brca1 蛋白在 DNA 修复、肿瘤发生和抗癌治疗中的功能的意义。
