Olsen J H, Jensen O M, Kampstrup O
Scand J Work Environ Health. 1986;12 Suppl 1:48-52.
Cancer incidence was studied among 5,317 employees in one rock-wool production plant in Denmark. During the period 1943--1982 a marginally significant excess of 240 cancer cases was observed versus 211.0 cases expected. Among the subgroup of male workers an increasing risk with time since first employment was observed for cancer of the buccal cavity and pharynx, cancer of the respiratory system, and cancer of the bladder, of which only the excess of the first-mentioned reached significance. The increased risk of lung cancer among male workers with 20 or more years since first employment, which was not significantly in excess of 1.0, although still compatible with a two- to threefold increase according to conventional 95% confidence limits, could not be explained by deviations in local lung cancer incidence, place of residence among the rock-wool male workers, or smoking habits prevailing among unskilled workers in the eastern part of Denmark. The number of cases, however, was too small to exclude the effect of chance in this single investigation.
对丹麦一家岩棉生产厂的5317名员工的癌症发病率进行了研究。在1943年至1982年期间,观察到240例癌症病例,略高于预期的211.0例,差异具有边际显著性。在男性工人亚组中,自首次就业以来,口腔和咽部癌症、呼吸系统癌症以及膀胱癌的风险随时间增加,其中只有上述第一种癌症的超额发病率具有显著性。首次就业20年或更长时间的男性工人患肺癌的风险增加,虽然按照传统的95%置信区间仍与两到三倍的增加相符,但并未显著超过1.0,这无法通过当地肺癌发病率的偏差、岩棉男性工人的居住地点或丹麦东部非技术工人普遍的吸烟习惯来解释。然而,病例数量太少,无法在这项单一调查中排除偶然性的影响。