Stockholm University, Department of Mathematics, SE-106 91 Stockholm, Sweden; KTH Royal Institute of Technology, Dept of Computational Science and Technology, 100 44 Stockholm, Sweden; SeRC (Swedish e-Science Research Center), Sweden.
KTH Royal Institute of Technology, Dept of Computational Science and Technology, 100 44 Stockholm, Sweden.
Curr Opin Neurobiol. 2023 Dec;83:102809. doi: 10.1016/j.conb.2023.102809. Epub 2023 Nov 18.
Theories and models of working memory (WM) were at least since the mid-1990s dominated by the persistent activity hypothesis. The past decade has seen rising concerns about the shortcomings of sustained activity as the mechanism for short-term maintenance of WM information in the light of accumulating experimental evidence for so-called activity-silent WM and the fundamental difficulty in explaining robust multi-item WM. In consequence, alternative theories are now explored mostly in the direction of fast synaptic plasticity as the underlying mechanism. The question of non-Hebbian vs Hebbian synaptic plasticity emerges naturally in this context. In this review, we focus on fast Hebbian plasticity and trace the origins of WM theories and models building on this form of associative learning.
工作记忆 (WM) 的理论和模型至少自 20 世纪 90 年代中期以来就一直被持续活动假说所主导。过去十年，随着越来越多的实验证据表明存在所谓的活动静默 WM，以及难以解释稳健的多项目 WM，持续活动作为短期维持 WM 信息的机制的缺点引起了人们的关注。因此，现在主要从快速突触可塑性的方向探索替代理论作为潜在机制。在这种情况下，非海伯式与海伯式突触可塑性的问题自然出现。在这篇综述中，我们专注于快速海伯式可塑性，并追溯基于这种形式的联想学习的 WM 理论和模型的起源。
