Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, the Netherlands.
Eodyne Systems SL, Barcelona, Spain; Department of Information and Communication Technologies, Universitat Pompeu Fabra (UPF), Barcelona, Spain. Electronic address: https://twitter.com/@francpsantos.
Curr Opin Neurobiol. 2023 Dec;83:102807. doi: 10.1016/j.conb.2023.102807. Epub 2023 Nov 17.
Advancements in stroke rehabilitation remain limited and call for a reorientation. Based on recent results, this study proposes a network-centric perspective on stroke, positing that it not only causes localized deficits but also affects the brain's intricate network of networks, transiting it into a pathological state. Translating these system-level insights into interventions requires brain theory, and the Distributed Adaptive Control (DAC) theory offers such a framework. When applied in the rehabilitation gaming system, these principles demonstrate superior results over conventional methods. This impact stems from activating extensive brain networks, particularly the executive control network, focused motor learning, and maintaining excitatory-inhibitory balance, which is essential for neural repair and functional reorganization. The analysis stresses uniting preclinical and clinical research and placing the architecture of the embodied volitional brain at the centre of rehabilitation approaches.
脑卒中康复的进展仍然有限，需要重新定位。基于最近的研究结果，本研究提出了一种以网络为中心的脑卒中观点，认为脑卒中不仅会导致局部缺陷，还会影响大脑复杂的网络系统，使其进入病理状态。将这些系统层面的见解转化为干预措施需要脑理论，而分布式自适应控制（DAC）理论提供了这样一个框架。当将这些原理应用于康复游戏系统时，它们的效果优于传统方法。这种影响源于激活广泛的大脑网络，特别是执行控制网络、聚焦运动学习和维持兴奋性抑制性平衡，这对于神经修复和功能重组至关重要。分析强调了将临床前和临床研究结合起来，并将具身意志大脑的结构置于康复方法的中心。
