用于体积受限药物分析的摩擦电纳米发电机涂层刀片喷雾质谱法。
Triboelectric Nanogenerator-Coated Blade Spray Mass Spectrometry for Volume-Limited Drug Analysis.
作者信息
Ma Xin, Fernández Facundo M
机构信息
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332.
Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332.
出版信息
Int J Mass Spectrom. 2024 Jan;495. doi: 10.1016/j.ijms.2023.117164. Epub 2023 Oct 20.
The demand for analytical tools for the analysis of low-concentration volume-limited samples has driven researchers to explore new analytical approaches. Mass spectrometry excels at trace analysis due to its high sensitivity and specificity, whereas ambient methods simplify, or completely eliminate sample preparation. Herein, we report a triboelectric nanogenerator-coated blade spray ambient mass spectrometry (TENG-CBS MS) method for the extraction, elution, and ionization of volume-limited, low-concentration small molecule drug samples with minimum sample preparation. Using a TENG device as the CBS power supply, we show it is possible to extract and analyze drug samples in a pulsed fashion at sub-nanogram to picogram levels with good stability and reproducibility. A wide range of analytes polarities were tested. Results indicated this method could also be useful for the analysis of low-level analytes in precious, volume limited samples in a simple single step.
对用于分析低浓度、体积受限样品的分析工具的需求促使研究人员探索新的分析方法。质谱由于其高灵敏度和特异性而在痕量分析方面表现出色，而常压方法则简化或完全消除了样品制备过程。在此，我们报告了一种摩擦电纳米发电机涂层刀片喷雾常压质谱（TENG-CBS MS）方法，用于以最少的样品制备对体积受限、低浓度的小分子药物样品进行提取、洗脱和电离。使用摩擦电纳米发电机（TENG）装置作为CBS电源，我们证明了能够以亚纳克到皮克水平的脉冲方式提取和分析药物样品，具有良好的稳定性和重现性。测试了多种分析物极性。结果表明，该方法还可用于以简单的单步方式分析珍贵的、体积受限样品中的低水平分析物。
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