Lin Min, Wu Yu-Fei, Liu Zheng-Qiang, Liang Cheng, Li Qing-Hua, Liu Tang-Lin
School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
Chem Commun (Camb). 2023 Dec 5;59(97):14431-14434. doi: 10.1039/d3cc04665f.
Rhodium-catalyzed three-component C-H bond activation of aromatics with amides and aldehydes to synthesize amines was established. The addition of copper was found to be essential to ensure the high reactivity. The mechanistic studies indicated that key intermediates formed by the transmetallization between rhodium and copper could further promote the addition between 2-(pyridin-2-yl)-phenyl-metal species and imines. A series of densely substituted amines could be conveniently prepared by this one-step, three-component procedure from commercially available substrates C-H bond activation with water as the only by-product.
建立了铑催化芳烃与酰胺和醛的三组分C-H键活化反应以合成胺类化合物的方法。发现添加铜对于确保高反应活性至关重要。机理研究表明，铑与铜之间通过金属转移形成的关键中间体可进一步促进2-(吡啶-2-基)-苯基金属物种与亚胺之间的加成反应。通过这种一步法三组分反应，以水为唯一副产物，可方便地从市售底物制备一系列高度取代的胺类化合物。
