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铑(III)催化 Boc-亚胺通过 C-H 键功能化的芳基化反应。

Rhodium(III)-catalyzed arylation of Boc-imines via C-H bond functionalization.

机构信息

Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.

出版信息

J Am Chem Soc. 2011 Feb 9;133(5):1248-50. doi: 10.1021/ja109562x. Epub 2011 Jan 4.

DOI:10.1021/ja109562x
PMID:21204527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3045530/
Abstract

The first rhodium-catalyzed arylation of imines proceeding via C-H bond functionalization is reported. Use of a non-coordinating halide abstractor is important to obtain reactivity. Aryl-branched N-Boc-amines are formed, and a wide range of functionality is compatible with the reaction.

摘要

首次报道了通过 C-H 键功能化进行的铑催化亚胺芳基化反应。使用非配位卤化物清除剂对于获得反应活性很重要。形成了支链芳基-N-Boc-胺，并且该反应与广泛的官能团兼容。

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