Anatomical Pathology, PathWest Laboratory Medicine, J Block QEII Medical Centre, Nedlands, Perth, Australia.
The University of Western Australia, Perth, Australia; and.
Am J Dermatopathol. 2024 Feb 1;46(2):98-100. doi: 10.1097/DAD.0000000000002596. Epub 2023 Nov 14.
The distinction between digital papillary adenocarcinoma (DPAC) and benign cutaneous adnexal tumors is clinically important and can be challenging. Poroid hidradenoma frequently occurs at acral sites and can show a number of histological features, which overlap with digital papillary adenocarcinoma. Recent work has shown that YAP1-NUTM1 fusions are frequent in poroid hidradenoma and are associated with nuclear protein in testis (NUT) expression by immunohistochemistry. We evaluated the expression of NUT-1 by immunohistochemistry in 4 cases of DPAC and 4 cases of poroid hidradenoma. Three of 4 cases of poroid hidradenoma showed strong NUT-1 expression, with no staining in any of the cases of DPAC. These results suggest that NUT-1 immunohistochemistry may be a useful additional tool in evaluating this differential diagnosis.
数字乳头状腺癌 (DPAC) 和良性皮肤附属器肿瘤的鉴别在临床上很重要，但具有一定挑战性。汗管瘤常发生于肢端部位，且具有多种与 DPAC 重叠的组织学特征。最近的研究表明，poroid hidradenoma 中常出现 YAP1-NUTM1 融合，并通过免疫组化显示核蛋白在睾丸（NUT）的表达。我们通过免疫组化评估了 4 例 DPAC 和 4 例 poroid hidradenoma 中 NUT-1 的表达。4 例 poroid hidradenoma 中有 3 例表现出强烈的 NUT-1 表达，而 DPAC 中无一例染色。这些结果表明，NUT-1 免疫组化可能是评估这种鉴别诊断的有用附加工具。
