细胞类型特异性需要 Ddx3 和 PACT 来诱导 RNA 病毒的干扰素反应。
Cell-type-specific need of Ddx3 and PACT for interferon induction by RNA viruses.
机构信息
Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
出版信息
J Virol. 2023 Dec 21;97(12):e0130423. doi: 10.1128/jvi.01304-23. Epub 2023 Nov 20.
Interferon-stimulated genes (ISGs) are induced in response to interferon expression due to viral infections. Role of these ISGs can be variable in different cells or organs. Our study highlights such cell-specific role of an ISG, Ddx3, which regulates the translation of mRNAs essential for interferon induction (PACT) and interferon signaling (STAT1) in a cell-specific manner. Our study also highlights the role of PACT in RNA virus-induced RLR signaling. Our study depicts how Ddx3 regulates innate immune signaling pathways in an indirect manner. Such cell-specific behavior of ISGs helps us to better understand viral pathogenesis and highlights the complexities of viral tropism and innate immune responses.
干扰素刺激基因 (ISGs) 在病毒感染时因干扰素表达而被诱导。这些 ISGs 在不同细胞或器官中的作用可能不同。我们的研究强调了 ISG 中一种特定细胞的作用，即 Ddx3，它以细胞特异性的方式调节干扰素诱导 (PACT) 和干扰素信号 (STAT1) 所必需的 mRNA 的翻译。我们的研究还强调了 PACT 在 RNA 病毒诱导的 RLR 信号中的作用。我们的研究描述了 Ddx3 如何以间接的方式调节先天免疫信号通路。ISGs 的这种细胞特异性行为有助于我们更好地理解病毒发病机制，并突出了病毒嗜性和先天免疫反应的复杂性。
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