State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy Chengdu, 610041, Sichuan, P. R. China.
Department of Gynecology and Obstetrics, Development and Related Disease of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, 610041, Chengdu, P. R. China.
Signal Transduct Target Ther. 2021 Nov 26;6(1):402. doi: 10.1038/s41392-021-00791-1.
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation. Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway. Moreover, we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases.
Janus 激酶/信号转导子和转录激活子（JAK/STAT）信号通路在四分之一个多世纪前被发现。作为许多重要细胞过程的支点，JAK/STAT 通路构成了一个快速的膜到核信号模块，并诱导癌症和炎症的各种关键介质的表达。越来越多的证据表明，JAK/STAT 通路的失调与各种癌症和自身免疫性疾病有关。在这篇综述中，我们讨论了关于 JAK/STAT 通路的组成、激活和调节的现有知识。此外，我们强调了 JAK/STAT 通路及其抑制剂在各种疾病中的作用。
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