中枢神经系统弓形虫感染与自杀：一项关于死者的病例对照研究
Toxoplasma gondii infection of the central nervous system and suicide: A case-control study of decedents.
作者信息
Mendoza-Larios Laura Alejandra, García-Dolores Fernando, Sánchez-Anguiano Luis Francisco, Antuna-Salcido Elizabeth Irasema, Hernández-Tinoco Jesús, Rocha-Salais Adriana, Segoviano-Mendoza Marcela Araceli, Sifuentes-Álvarez Antonio, Alvarado-Esquivel Cosme
机构信息
1Instituto de Ciencias Forenses de la Ciudad de México, Avenida Niños Héroes 130, Colonia Doctores, Delegación Cuauhtémoc, 06720 Ciudad de México, Mexico.
2Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N. 34000 Durango, Mexico.
出版信息
Eur J Microbiol Immunol (Bp). 2023 Nov 20;13(3):77-82. doi: 10.1556/1886.2023.00033. Print 2023 Nov 23.
We sought to determine the association between Toxoplasma gondii (T. gondii) infection of the central nervous system and suicide in a sample of decedents in Mexico City. One hundred and forty-seven decedents (87 who committed suicide and 60 who did not commit suicide) were studied. Brain tissues (amygdala and prefrontal cortex) of decedents were examined for the detection of T. gondii using immunohistochemistry. Detection of T. gondii was positive in 7 (8.0%) of the 87 cases (6 found in prefrontal cortex and one in amygdala), and in one (1.7%) of the 60 controls (found in prefrontal cortex) (OR: 5.16; 95% CI: 0.61-43.10; P = 0.14). Results suggest that T. gondii infection in brain is not associated with suicide. Further studies to confirm this finding are needed.
我们试图在墨西哥城的一组死者样本中确定中枢神经系统弓形虫感染与自杀之间的关联。研究了147名死者（87名自杀者和60名非自杀者）。使用免疫组织化学检查死者的脑组织（杏仁核和前额叶皮质）以检测弓形虫。87例中有7例（8.0%）弓形虫检测呈阳性（6例在前额叶皮质，1例在杏仁核），60例对照中有1例（1.7%）呈阳性（在前额叶皮质）（比值比：5.16；95%置信区间：0.61 - 43.10；P = 0.14）。结果表明脑部弓形虫感染与自杀无关。需要进一步研究来证实这一发现。
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