Alvarado-Esquivel Cosme, Mendoza-Larios Laura Alejandra, García-Dolores Fernando, Sánchez-Anguiano Luis Francisco, Antuna-Salcido Elizabeth Irasema, Hernández-Tinoco Jesús, Rocha-Salais Adriana, Segoviano-Mendoza Marcela Araceli, Sifuentes-Álvarez Antonio
Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Durango 34000, Mexico.
Amphitheater and Department of Education, Institute of Forensic Sciences, Mexico 06720, Mexico.
Pathogens. 2021 Oct 13;10(10):1313. doi: 10.3390/pathogens10101313.
We assessed the association between () infection of the central nervous system and suicide correlates in suicide decedents. Eighty-seven decedents who died by suicide received in a forensic setting for medico-legal autopsies in Mexico City were studied. Two samples of brain (amygdala and prefrontal cortex) from each decedent were examined for detection of using immunohistochemistry. Correlates of suicide including a history of previous suicide attempts, co-morbid mental disorder, consumption of alcohol or tobacco, irritability and aggression, economic problems, presence of drugs or alcohol in blood and suicide method were obtained and analyzed for their association with infection. immunohistochemistry was positive in prefrontal cortex sections in 6 decedents and in an amygdala section in one decedent. Thus, the prevalence of infection in brain in suicide victims was 8.0% (7/87). Bivariate and logistic regression analysis of suicide correlates showed that only a history of depression was associated with infection of the brain in suicide victims (OR: 12.00; 95% CI: 2.26-63.46; = 0.003). Our results provide evidence that infection in brain is associated with a history of depression in suicide decedents.
我们评估了中枢神经系统（）感染与自杀死亡者自杀相关因素之间的关联。对在墨西哥城法医环境中接受法医学尸检的87例自杀死亡者进行了研究。对每位死者的两份脑样本（杏仁核和前额叶皮质）进行检查，采用免疫组织化学方法检测（）。获取自杀相关因素，包括既往自杀未遂史、共病精神障碍、酒精或烟草消费、易怒和攻击性、经济问题、血液中药物或酒精的存在以及自杀方式，并分析它们与（）感染的关联。免疫组织化学显示，6例死者的前额叶皮质切片呈阳性，1例死者的杏仁核切片呈阳性。因此，自杀受害者脑中（）感染的患病率为8.0%（7/87）。对自杀相关因素的双变量和逻辑回归分析表明，只有抑郁症病史与自杀受害者脑中（）感染相关（比值比：12.00；95%置信区间：2.26 - 63.46；P = 0.003）。我们的结果提供了证据，表明自杀死亡者脑中（）感染与抑郁症病史相关。
